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AREA MIN. 11 – Scienze storiche, filosofiche, pedagogiche e psicologiche – 10-13 giugno 2015

Authors: AREA MIN. 11 - Scienze storiche, filosofiche, pedagogiche e psicologiche; ITA

Published: 1727232366656

26/02/2026 10:49:26

Authors: 500 111 RIVER ST, HOBOKEN 07030-5774, NJ USA; 2-s2.0-85007477063 27873319

Journal: Italy||Italy||Germany||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy

Published: cc-by

DOI: University and Hospital Trust of Verona||University and Hospital Trust of Verona||Max-Planck-Institut für Immunbiologie und Epigenetik Freiburg||University of Padua||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University of Genova and IRCCS S. Martino-IST University Hospital||University and Hospital Trust of Verona||University of Genova and IRCCS S. Martino-IST University Hospital||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University and Hospital Trust of Pisa||Università degli Studi di Milano||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University of Pisa||University of Turin at San Luigi Hospital||University and Hospital Trust of Verona

eng

Volume: Simbolo M.; Mafficini A.; Sikora K.O.; Fassan M.; Barbi S.; Corbo V.; Mastracci L.; Rusev B.; Grillo F.; Vicentini C.; Ferrara R.; Pilotto S.; Davini F.; Pelosi G.; Lawlor R.T.; Chilosi M.; Tortora G.; Bria E.; Fontanini G.; Volante M.; Scarpa A. Pages: Simbolo||Mafficini||Sikora||Fassan||Barbi||Corbo||Mastracci||Rusev||Grillo||Vicentini||Ferrara||Pilotto||Davini||Pelosi||Lawlor||Chilosi||Tortora||Bria||Fontanini||Volante||Scarpa-Next-generation sequencing (NGS) was applied to 148 lung neuroendocrine tumours (LNETs) comprising the four World Health Organization classification categories: 53 typical carcinoid (TCs), 35 atypical carcinoid (ACs), 27 large-cell neuroendocrine carcinomas, and 33 small-cell lung carcinomas. A discovery screen was conducted on 46 samples by the use of whole-exome sequencing and high-coverage targeted sequencing of 418 genes. Eighty-eight recurrently mutated genes from both the discovery screen and current literature were verified in the 46 cases of the discovery screen, and validated on additional 102 LNETs by targeted NGS; their prevalence was then evaluated on the whole series. Thirteen of these 88 genes were also evaluated for copy number alterations (CNAs). Carcinoids and carcinomas shared most of the altered genes but with different prevalence rates. When mutations and copy number changes were combined, MEN1 alterations were almost exclusive to carcinoids, whereas alterations of TP53 and RB1 cell cycle regulation genes and PI3K/AKT/mTOR pathway genes were significantly enriched in carcinomas. Conversely, mutations in chromatin-remodelling genes, including those encoding histone modifiers and members of SWI–SNF complexes, were found at similar rates in carcinoids (45.5%) and carcinomas (55.0%), suggesting a major role in LNET pathogenesis. One AC and one TC showed a hypermutated profile associated with a POLQ damaging mutation. There were fewer CNAs in carcinoids than in carcinomas; however ACs showed a hybrid pattern, whereby gains of TERT, SDHA, RICTOR, PIK3CA, MYCL and SRC were found at rates similar to those in carcinomas, whereas the MEN1 loss rate mirrored that of TCs. Multivariate survival analysis revealed RB1 mutation (p = 0.0005) and TERT copy gain (p = 0.016) as independent predictors of poorer prognosis. MEN1 mutation was associated with poor prognosis in AC (p = 0.0045), whereas KMT2D mutation correlated with longer survival in SCLC (p = 0.0022). In conclusion, molecular profiling may complement histology for better diagnostic definition and prognostic stratification of LNETs. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

15/03/2026 06:40:12

Authors: HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY; 2-s2.0-85046880720 29740198

Journal: Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy

Published: cc-by

DOI: University and Hospital Trust of Verona||University and Hospital Trust of Verona||University of Verona||University and Hospital Trust of Verona||University of Verona||University of Padua||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University and Hospital Trust of Verona||Fondazione Policlinico 'A. Gemelli'||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University and Hospital Trust of Verona||University of Verona||University of Verona||University and Hospital Trust of Verona

eng

Volume: Simbolo M.; Vicentini C.; Ruzzenente A.; Brunelli M.; Conci S.; Fassan M.; Mafficini A.; Rusev B.; Corbo V.; Capelli P.; Bria E.; Pedron S.; Turri G.; Lawlor R.T.; Tortora G.; Bassi C.; Guglielmi A.; Scarpa A. Pages: Simbolo||Vicentini||Ruzzenente||Brunelli||Conci||Fassan||Mafficini||Rusev||Corbo||Capelli||Bria||Pedron||Turri||Lawlor||Tortora||Bassi||Guglielmi||Scarpa-The incidence and mortality rates of intrahepatic cholangiocarcinoma have been rising worldwide. Few patients present an early-stage disease that is amenable to curative surgery and after resection, high recurrence rates persist. To identify new independent marker related to aggressive behaviour, two prognostic groups of patient were selected and divided according to prognostic performance. All patients alive at 36 months were included in good prognostic performers, while all patients died due to disease within 36 months in poor prognostic performers. Using high-coverage target sequencing we analysed principal genetic alterations in two groups and compared results to clinical data. In the 33 cases included in poor prognosis group, TP53 was most mutated gene (p = 0.011) and exclusively present in these cases. Similarly, ARID1A was exclusive of this group (p = 0.024). TP53 and ARID1A are mutually exclusive in this study. Statistical analysis showed mutations in TP53 and ARID1A genes and amplification of MET gene as independent predictors of poor prognosis (TP53, p = 0.0031, ARID1A, p = 0.0007, MET, p = 0.0003 in Cox analysis). LOH in PTEN was also identified as marker of disease recurrence (p = 0.04) in univariate analysis. This work improves our understanding of aggressiveness related to this tumour type and has identified novel prognostic markers of clinical outcome.

22/04/2026 03:27:31

Authors: 2-s2.0-85044833318 29707122

Journal: Laser ablation is superior to TACE in large-sized hepatocellular carcinoma: A pilot case-control study

Published: cc-by

DOI: 25

eng

Volume: Morisco F.; Camera S.; Guarino M.; Tortora R.; Cossiga V.; Vitiello A.; Cordone G.; Caporaso N.; Di Costanzo G.G.; Zoli M.; Garuti F.; Neri A.; Piscaglia F.; Lenzi B.; Valente M.; Trevisani F.; Bolondi L.; Biselli M.; Caraceni P.; Cucchetti A.; Domenicali M.; Gramenzi A.; Magalotti D.; Serra C.; Venerandi L.; Cappelli A.; Golfieri R.; Mosconi C.; Renzulli M.; Giannini E.G.; Brunacci M.; Moscatelli A.; Pellegatta G.; Savarino V.; Caturelli E.; Roselli P.; Lauria V.; Pelecca G.; Dell'Isola S.; Ialungo A.M.; Rastrelli E.; Cabibbo G.; Camma C.; Attardo S.; Rossi M.; Cavani G.; Virdone R.; Affronti A.; Nardone G.; Felder M.; Mega A.; Ciccarese F.; Del Poggio P.; Olmi S.; Foschi F.G.; Bevilacqua V.; Dall'Aglio A.C.; Ercolani G.; Fiorini E.; Casadei Gardini A.; Lanzi A.; Mirici Cappa F.; Sacco R.; Mismas V.; Svegliati Barone G.; Schiada L.; Farinati F.; Gazzola A.; Murer F.; Pozzan C.; Vanin V.; Rapaccini G.L.; de Matthaeis N.; Gasbarrini A.; Rinninella E.; Olivani A.; Missale G.; Biasini E.; Di Marco M.; Balsamo C.; Vavassori E.; Masotto A.; Marchetti F.; Valerio M.; Marra F.; Aburas S.; Campani C.; Dragoni G.; Borzio F.; Benvegnu L.; Festi D.; Marasco G.; Ravaioli F.

18/04/2026 07:33:22

Authors: 90 THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND; 2-s2.0-85034811740

Journal: France||Germany||United States||Switzerland||Italy||Germany||United States||Italy||France||France||Germany||Italy||Italy||United States||United States||United Kingdom||United States||France||United States||Italy||Italy||United States||United States||Finland||United States||Germany||France||Switzerland||France||United States||Italy

Published: cc-by-nc-nd

DOI: Université de Nantes||University of Heidelberg||Massachusetts Institute of Technology||University of Bern||University of Bologna||University of Leipzig||University of Idaho||Thales Alenia Space||LATMOS||Univ. Paris-Diderot||DLR||Thales Alenia Space||University of Padova -CISAS||Cornell University||California Institute of Technology||University of Kent||University of Colorado||LPC2E||JHU Applied Physics Laboratory||Thales Alenia Space||INAF||California Institute of Technology||California Institute of Technology||University of Oulu||California Institute of Technology||University of Stuttgart||Université de Nantes||University of Bern||IPAG||California Institute of Technology||University of Bologna

eng

Volume: Mitri G.; Postberg F.; Soderblom J.M.; Wurz P.; Tortora P.; Abel B.; Barnes J.W.; Berga M.; Carrasco N.; Coustenis A.; Paul de Vera J.P.; D'Ottavio A.; Ferri F.; Hayes A.G.; Hayne P.O.; Hillier J.K.; Kempf S.; Lebreton J.-P.; Lorenz R.D.; Martelli A.; Orosei R.; Petropoulos A.E.; Reh K.; Schmidt J.; Sotin C.; Srama R.; Tobie G.; Vorburger A.; Vuitton V.; Wong A.; Zannoni M. Pages: Mitri||Postberg||Soderblom||Wurz||Tortora||Abel||Barnes||Berga||Carrasco||Coustenis||Paul de Vera||D'Ottavio||Ferri||Hayes||Hayne||Hillier||Kempf||Lebreton||Lorenz||Martelli||Orosei||Petropoulos||Reh||Schmidt||Sotin||Srama||Tobie||Vorburger||Vuitton||Wong||Zannoni-Titan, with its organically rich and dynamic atmosphere and geology, and Enceladus, with its active plume, both harbouring global subsurface oceans, are prime environments in which to investigate the habitability of ocean worlds and the conditions for the emergence of life. We present a space mission concept, the Explorer of Enceladus and Titan (E2T), which is dedicated to investigating the evolution and habitability of these Saturnian satellites. E2T is proposed as a medium-class mission led by ESA in collaboration with NASA in response to ESA's M5 Cosmic Vision Call. E2T proposes a focused payload that would provide in-situ composition investigations and high-resolution imaging during multiple flybys of Enceladus and Titan using a solar-electric powered spacecraft in orbit around Saturn. The E2T mission would provide high-resolution mass spectrometry of the plume currently emanating from Enceladus' south polar terrain and of Titan's changing upper atmosphere. In addition, high-resolution infrared (IR) imaging would detail Titan's geomorphology at 50–100 m resolution and the temperature of the fractures on Enceladus' south polar terrain at meter resolution. These combined measurements of both Titan and Enceladus would enable the E2T mission scenario to achieve two major scientific goals: 1) Study the origin and evolution of volatile-rich ocean worlds; and 2) Explore the habitability and potential for life in ocean worlds. E2T's two high-resolution time-of-flight mass spectrometers would enable resolution of the ambiguities in chemical analysis left by the NASA/ESA/ASI Cassini-Huygens mission regarding the identification of low-mass organic species, detect high-mass organic species for the first time, further constrain trace species such as the noble gases, and clarify the evolution of solid and volatile species. The high-resolution IR camera would reveal the geology of Titan's surface and the energy dissipated by Enceladus' fractured south polar terrain and plume in detail unattainable by the Cassini mission.

26/02/2026 10:26:52

Authors: 162 STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA; 2-s2.0-85032887534 29102521

Journal: Effect of direct-acting antivirals on future occurrence of hepatocellular carcinoma in compensated cirrhotic patients

Published: cc-by

DOI: 2

eng

Volume: Cucchetti A.; D'amico G.; Trevisani F.; Morelli M.C.; Vitale A.; Pinna A.D.; Cescon M.; Cillo U.; Burra P.; Russo F.P.; Mescoli C.; Rendina M.; Lupo L.G.; Losito F.; Fucilli F.; Brancaccio G.-P.; Persico M.; Vigano L.; Iavarone M.; D'ambrosio R.; Sangiovanni A.; Renzulli M.; Galati G.; Ponziani F.R.; Pompili M.; Miele L.; Grieco A.; Rapaccini G.; Gasbarrini A.; Sandri G.B.L.; Lai Q.; Melandro F.; Rossi M.; Lenci I.; Manzia T.M.; Tortora R.; Di Costanzo G.G.; Sacco R.; Simonetti N.; Morisco F.; Guarino M.; Cabibbo G.; Bhoori C.S.S.; Di Sandro S.; Foschi F.G.; Gardini A.C.; Nicolini D.; Mazzocato S.; Alba K.; Violi P.; Baccarani U.; Pravisani R.

17/03/2026 06:02:23

Authors: 1114 STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA; 2-s2.0-85052759999 30170908

Journal: Recurrence of hepatocellular carcinoma after direct acting antiviral treatment for hepatitis C virus infection: Literature review and risk analysis

Published: cc-by

DOI: 11

eng

Volume: Guarino M.; Vigano L.; Ponziani F.R.; Giannini E.G.; Lai Q.; Morisco F.; Vitale A.; Russo F.P.; Cillo U.; Burra P.; Mescoli C.; Gambato M.; Sessa A.; Cabibbo G.; Vigano M.; Galati G.; Villa E.; Iavarone M.; Brancaccio G.; Rendina M.; Lupo L.G.; Losito F.; Fucilli F.; Persico M.; D'Ambrosio R.; Sangiovanni A.; Cucchetti A.; Trevisani e Matteo Renzulli F.; Miele L.; Grieco A.; Lodovico Rapaccini G.; Pompili M.; Gasbarrini A.; Battisa Levi Sandri G.; Melandro F.; Rossi M.; Lenci I.; Manzia T.M.; Tortora R.; Di Costanzo G.G.; Sacco R.; Ghinolfi D.; Rreka E.; Carrai P.; Simonetti N.; Sposito C.; Bhoori S.; di Sandro S.; Foschi F.G.; Casadei Gardini A.; Nicolini D.; Mazzocato S.; Kostandini A.; Violi P.; Baccarani U.; Pravisani R.; Vincenzi V.

21/03/2026 06:58:20

Authors: 2595 8226 REGENCY DR, PLEASANTON, CA 94588 USA; 2-s2.0-85049299671 29962815

Journal: Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows

Published: cc-by-nc

DOI: 24

eng

Volume: Guarino M.; Sessa A.; Cossiga V.; Morando F.; Caporaso N.; Morisco F.; Luca V.; Romana P.F.; Maurizio P.; Cillo U.; Burra P.; Mescoli C.; Gambato M.; Paolo R.F.; Alessandro V.; Giuseppe C.; Mauro V.; Giovanni G.; Erica V.; Lupo L.G.; Maria R.; Losito F.; Fucilli F.; Persico M.; D'Ambrosio R.; Sangiovanni A.; Massimo I.; Giuseppina B.; Cucchetti A.; Renzulli M.; Franco T.; Miele L.; Grieco A.; Rapaccini G.; Gasbarrini A.; Sandri G.B.L.; Melandro F.; Rossi M.; Quirino L.; Lenci I.; Manzia T.M.; Tortora R.; Di Costanzo G.G.; Ghinolfi D.; Rreka E.; Carrai P.; Simonetti N.; Rodolfo S.; Sposito C.; Bhoori S.; Di Sandro S.; Foschi F.G.; Gardini A.C.; Nicolini D.; Mazzocato S.; Alba K.; Violi P.; Baccarani U.; Pravisani R.; Vincenzi V.

2023/07/07 09:44:11

Authors: AREA MIN. 06 - Scienze mediche; Non assegn

Published: 1777505435045

06/03/2026 04:27:37

Authors: 1114 STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA; 2-s2.0-85052759999 30170908

Journal: Recurrence of hepatocellular carcinoma after direct acting antiviral treatment for hepatitis C virus infection: Literature review and risk analysis

Published: cc-by

DOI: 11

eng

Volume: Guarino M.; Vigano L.; Ponziani F.R.; Giannini E.G.; Lai Q.; Morisco F.; Vitale A.; Russo F.P.; Cillo U.; Burra P.; Mescoli C.; Gambato M.; Sessa A.; Cabibbo G.; Vigano M.; Galati G.; Villa E.; Iavarone M.; Brancaccio G.; Rendina M.; Lupo L.G.; Losito F.; Fucilli F.; Persico M.; D'Ambrosio R.; Sangiovanni A.; Cucchetti A.; Trevisani e Matteo Renzulli F.; Miele L.; Grieco A.; Lodovico Rapaccini G.; Pompili M.; Gasbarrini A.; Battisa Levi Sandri G.; Melandro F.; Rossi M.; Lenci I.; Manzia T.M.; Tortora R.; Di Costanzo G.G.; Sacco R.; Ghinolfi D.; Rreka E.; Carrai P.; Simonetti N.; Sposito C.; Bhoori S.; di Sandro S.; Foschi F.G.; Casadei Gardini A.; Nicolini D.; Mazzocato S.; Kostandini A.; Violi P.; Baccarani U.; Pravisani R.; Vincenzi V.

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