IAS-LAB PUBLICATIONS
13/05/2026 03:01:16
Authors: HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY; 2-s2.0-85079060258 32024854
Journal: Pathway and network analysis of more than 2500 whole cancer genomes
Published: cc-by
DOI: 1
eng
Volume: Reyna M.A.; Haan D.; Paczkowska M.; Verbeke L.P.C.; Vazquez M.; Kahraman A.; Pulido-Tamayo S.; Barenboim J.; Wadi L.; Dhingra P.; Shrestha R.; Getz G.; Lawrence M.S.; Pedersen J.S.; Rubin M.A.; Wheeler D.A.; Brunak S.; Izarzugaza J.M.G.; Khurana E.; Marchal K.; von Mering C.; Sahinalp S.C.; Valencia A.; Abascal F.; Amin S.B.; Bader G.D.; Bandopadhayay P.; Beroukhim R.; Bertl J.; Boroevich K.A.; Busanovich J.; Campbell P.J.; Carlevaro-Fita J.; Chakravarty D.; Chan C.W.Y.; Chen K.; Choi J.K.; Deu-Pons J.; Diamanti K.; Feuerbach L.; Fink J.L.; Fonseca N.A.; Frigola J.; Gambacorti-Passerini C.; Garsed D.W.; Gerstein M.; Guo Q.; Gut I.G.; Hamilton M.P.; Haradhvala N.J.; Harmanci A.O.; Helmy M.; Herrmann C.; Hess J.M.; Hobolth A.; Hodzic E.; Hong C.; Hornshoj H.; Isaev K.; Johnson R.; Johnson T.A.; Juul M.; Juul R.I.; Kahles A.; Kellis M.; Kim J.; Kim J.K.; Kim Y.; Komorowski J.; Korbel J.O.; Kumar S.; Lanzos A.; Larsson E.; Lee D.; Lehmann K.-V.; Li S.; Li X.; Lin Z.; Liu E.M.; Lochovsky L.; Lou S.; Madsen T.; Martincorena I.; Martinez-Fundichely A.; Maruvka Y.E.; McGillivray P.D.; Meyerson W.; Muinos F.; Mularoni L.; Nakagawa H.; Nielsen M.M.; Park K.; Park K.; Pons T.; Reyes-Salazar I.; Rheinbay E.; Rubio-Perez C.; Saksena G.; Salichos L.; Sander C.; Schumacher S.E.; Shackleton M.; Shapira O.; Shen C.; Shuai S.; Sidiropoulos N.; Sieverling L.; Sinnott-Armstrong N.; Stein L.D.; Tamborero D.; Tiao G.; Tsunoda T.; Umer H.M.; Uuskula-Reimand L.; Wadelius C.; Wang J.; Warrell J.; Waszak S.M.; Weischenfeldt J.; Wu G.; Yu J.; Zhang J.; Zhang X.; Zhang Y.; Zhao Z.; Zou L.; Reimand J.; Stuart J.M.; Raphael B.J.; Aaltonen L.A.; Abascal F.; Abeshouse A.; Aburatani H.; Adams D.J.; Agrawal N.; Ahn K.S.; Ahn S.-M.; Aikata H.; Akbani R.; Akdemir K.C.; Al-Ahmadie H.; Al-Sedairy S.T.; Al-Shahrour F.; Alawi M.; Albert M.; Aldape K.; Alexandrov L.B.; Ally A.; Alsop K.; Alvarez E.G.; Amary F.; Amin S.B.; Aminou B.; Ammerpohl O.; Anderson M.J.; Ang Y.; Antonello D.; Anur P.; Aparicio S.; Appelbaum E.L.; Arai Y.; Aretz A.; Arihiro K.; Ariizumi S.-I.; Armenia J.; Arnould L.; Asa S.; Assenov Y.; Atwal G.; Aukema S.; Auman J.T.; Aure M.R.R.; Awadalla P.; Aymerich M.; Baez-Ortega A.; Bailey M.H.; Bailey P.J.; Balasundaram M.; Balu S.; Bandopadhayay P.; Banks R.E.; Barbi S.; Barbour A.P.; Barenboim J.; Barnholtz-Sloan J.; Barr H.; Barrera E.; Bartlett J.; Bartolome J.; Bassi C.; Bathe O.F.; Baumhoer D.; Bavi P.; Baylin S.B.; Bazant W.; Beardsmore D.; Beck T.A.; Behjati S.; Behren A.; Niu B.; Bell C.; Beltran S.; Benz C.; Berchuck A.; Bergmann A.K.; Bergstrom E.N.; Berman B.P.; Berney D.M.; Bernhart S.H.; Berrios M.; Bersani S.; Bertl J.; Betancourt M.; Bhandari V.; Bhosle S.G.; Biankin A.V.; Bieg M.; Bigner D.; Binder H.; Birney E.; Birrer M.; Biswas N.K.; Bjerkehagen B.; Bodenheimer T.; Boice L.; Bonizzato G.; De Bono J.S.; Boot A.; Bootwalla M.S.; Borg A.; Borkhardt A.; Boroevich K.A.; Borozan I.; Borst C.; Bosenberg M.; Bosio M.; Boultwood J.; Bourque G.; Boutros P.C.; Bova G.S.; Bowen D.T.; Bowlby R.; Bowtell D.D.L.; Boyault S.; Boyce R.; Boyd J.; Brazma A.; Brennan P.; Brewer D.S.; Brinkman A.B.; Bristow R.G.; Broaddus R.R.; Brock J.E.; Brock M.; Broeks A.; Brooks A.N.; Brooks D.; Brors B.; Brunak S.; Bruxner T.J.C.; Bruzos A.L.; Buchanan A.; Buchhalter I.; Buchholz C.; Bullman S.; Burke H.; Burkhardt B.; Burns K.H.; Busanovich J.; Bustamante C.D.; Butler A.P.; Butte A.J.; Byrne N.J.; Borresen-Dale A.-L.; Caesar-Johnson S.J.; Cafferkey A.; Cahill D.; Calabrese C.; Caldas C.; Calvo F.; Camacho N.; Campo E.; Cantu C.; Cao S.; Carey T.E.; Carlevaro-Fita J.; Carlsen R.; Cataldo I.; Cazzola M.; Cebon J.; Cerfolio R.; Chadwick D.E.; Chakravarty D.; Chalmers D.; Chan C.W.Y.; Chan K.; Chan-Seng-Yue M.; Chandan V.S.; Chang D.K.; Chanock S.J.; Chantrill L.A.; Chateigner A.; Chatterjee N.; Chayama K.; Chen H.-W.; Chen J.; Chen K.; Chen Y.; Chen Z.; Cherniack A.D.; Chien J.; Chiew Y.-E.; Chin S.-F.; Cho J.; Cho S.; Choi W.; Chomienne C.; Chong Z.; Choo S.P.; Chou A.; Christ A.N.; Christie E.L.; Chuah E.; Cibulskis C.; Cibulskis K.; Cingarlini S.; Clapham P.; Claviez A.; Cleary S.; Cloonan N.; Cmero M.; Collins C.C.; Connor A.A.; Cooke S.L.; Cooper C.S.; Cope L.; Corbo V.; Cordes M.G.; Cordner S.M.; Cortes-Ciriano I.; Covington K.; Cowin P.A.; Craft B.; Craft D.; Creighton C.J.; Cun Y.; Curley E.; Cutcutache I.; Czajka K.; Czerniak B.; Dagg R.A.; Danilova L.; Davi M.V.; Davidson N.R.; Davies H.; Davis I.J.; Davis-Dusenbery B.N.; Dawson K.J.; De La Vega F.M.; De Paoli-Iseppi R.; Defreitas T.; Tos A.P.D.; Delaneau O.; Demchok J.A.; Demeulemeester J.; Demidov G.M.; Demircioglu D.; Dennis N.M.; Denroche R.E.; Dentro S.C.; Desai N.; Deshpande V.; Deshwar A.G.; Desmedt C.; Deu-Pons J.; Dhalla N.; Dhani N.C.; Dhingra P.; Dhir R.; DiBiase A.; Diamanti K.; Ding L.; Ding S.; Dinh H.Q.; Dirix L.; Doddapaneni H.V.; Donmez N.; Dow M.T.; Drapkin R.; Drechsel O.; Drews R.M.; Serge S.; Dudderidge T.; Dueso-Barroso A.; Dunford A.J.; Dunn M.; Dursi L.J.; Duthie F.R.; Dutton-Regester K.; Eagles J.; Easton D.F.; Edmonds S.; Edwards P.A.; Edwards S.E.; Eeles R.A.; Ehinger A.; Eils J.; Eils R.; El-Naggar A.; Eldridge M.; Ellrott K.; Erkek S.; Escaramis G.; Espiritu S.M.G.; Estivill X.; Etemadmoghadam D.; Eyfjord J.E.; Faltas B.M.; Fan D.; Fan Y.; Faquin W.C.; Farcas C.; Fassan M.; Fatima A.; Favero F.; Fayzullaev N.; Felau I.; Fereday S.; Ferguson M.L.; Ferretti V.; Feuerbach L.; Field M.A.; Fink J.L.; Finocchiaro G.; Fisher C.; Fittall M.W.; Fitzgerald A.; Fitzgerald R.C.; Flanagan A.M.; Fleshner N.E.; Flicek P.; Foekens J.A.; Fong K.M.; Fonseca N.A.; Foster C.S.; Fox N.S.; Fraser M.; Frazer S.; Frenkel-Morgenstern M.; Friedman W.; Frigola J.; Fronick C.C.; Fujimoto A.; Fujita M.; Fukayama M.; Fulton L.A.; Fulton R.S.; Furuta M.; Futreal P.A.; Fullgrabe A.; Gabriel S.B.; Gallinger S.; Gao J.; Gao S.; Garraway L.; Garred O.; Garrison E.; Garsed D.W.; Gehlenborg N.; Gelpi J.L.L.; George J.; Gerhard D.S.; Gerhauser C.; Gershenwald J.E.; Gerstung M.; Getz G.; Ghori M.; Ghossein R.; Giama N.H.; Gibbs R.A.; Gibson B.; Gill A.J.; Gill P.; Giri D.D.; Glodzik D.; Gnanapragasam V.J.; Goebler M.E.; Goldman M.J.; Gomez C.; Gonzalez S.; Gonzalez-Perez A.; Gordenin D.A.; Gossage J.; Gotoh K.; Govindan R.; Grabau D.; Graham J.S.; Grant R.C.; Green A.R.; Green E.; Greger L.; Grehan N.; Grimaldi S.; Grimmond S.M.; Grossman R.L.; Grundhoff A.; Gundem G.; Guo Q.; Gupta M.; Gupta S.; Gut I.G.; Gut M.; Goke J.; Ha G.; Haake A.; Haan D.; Haas S.; Haase K.; Haber J.E.; Habermann N.; Hach F.; Haider S.; Hama N.; Hamdy F.C.; Hamilton A.; Hamilton M.P.; Han L.; Hanna G.B.; Hansmann M.; Haradhvala N.J.; Harismendy O.; Harliwong I.; Harmanci A.O.; Harrington E.; Hasegawa T.; Haussler D.; Hawkins S.; Hayami S.; Hayashi S.; Hayes D.N.; Hayes S.J.; Hayward N.K.; Hazell S.; He Y.; Heath A.P.; Heath S.C.; Hedley D.; Hegde A.M.; Heiman D.I.; Heinold M.C.; Heins Z.; Heisler L.E.; Hellstrom-Lindberg E.; Helmy M.; Heo S.G.; Hepperla A.J.; Heredia-Genestar J.M.; Herrmann C.; Hersey P.; Hess J.M.; Hilmarsdottir H.; Hinton J.; Hirano S.; Hiraoka N.; Hoadley K.A.; Hobolth A.; Hodzic E.; Hoell J.I.; Hoffmann S.; Hofmann O.; Holbrook A.; Holik A.Z.; Hollingsworth M.A.; Holmes O.; Holt R.A.; Hong C.; Hong E.P.; Hong J.H.; Hooijer G.K.; Hornshoj H.; Hosoda F.; Hou Y.; Hovestadt V.; Howat W.; Hoyle A.P.; Hruban R.H.; Hu J.; Hu T.; Hua X.; Huang K.-L.; Huang M.; Huang M.N.; Huang V.; Huang Y.; Huber W.; Hudson T.J.; Hummel M.; Hung J.A.; Huntsman D.; Hupp T.R.; Huse J.; Huska M.R.; Hutter B.; Hutter C.M.; Hubschmann D.; Iacobuzio-Donahue C.A.; Imbusch C.D.; Imielinski M.; Imoto S.; Isaacs W.B.; Isaev K.; Ishikawa S.; Iskar M.; Islam S.M.A.; Ittmann M.; Ivkovic S.; Izarzugaza J.M.G.; Jacquemier J.; Jakrot V.; Jamieson N.B.; Jang G.H.; Jang S.J.; Jayaseelan J.C.; Jayasinghe R.; Jefferys S.R.; Jegalian K.; Jennings J.L.; Jeon S.-H.; Jerman L.; Ji Y.; Jiao W.; Johansson P.A.; Johns A.L.; Johns J.; Johnson R.; Johnson T.A.; Jolly C.; Joly Y.; Jonasson J.G.; Jones C.D.; Jones D.R.; Jones D.T.W.; Jones N.; Jones S.J.M.; Jonkers J.; Ju Y.S.; Juhl H.; Jung J.; Juul M.; Juul R.I.; Juul S.; Jager N.; Kabbe R.; Kahles A.; Kahraman A.; Kaiser V.B.; Kakavand H.; Kalimuthu S.; von Kalle C.; Kang K.J.; Karaszi K.; Karlan B.; Karlic R.; Karsch D.; Kasaian K.; Kassahn K.S.; Katai H.; Kato M.; Katoh H.; Kawakami Y.; Kay J.D.; Kazakoff S.H.; Kazanov M.D.; Keays M.; Kebebew E.; Kefford R.F.; Kench J.G.; Kennedy C.J.; Kerssemakers J.N.A.; Khoo D.; Khoo V.; Khuntikeo N.; Khurana E.; Kilpinen H.; Kim H.K.; Kim H.-L.; Kim H.-Y.; Kim H.; Kim J.; Kim J.; Kim J.K.; Kim Y.; King T.A.; Klapper W.; Kleinheinz K.; Klimczak L.J.; Knappskog S.; Kneba M.; Knoppers B.M.; Koh Y.; Jan Komorowski; Komura D.; Komura M.; Kong G.; Kool M.; Korbel J.O.; Korchina V.; Korshunov A.; Koscher M.; Koster R.; Kote-Jarai Z.; Koures A.; Kovacevic M.; Kremeyer B.; Kretzmer H.; Kreuz M.; Krishnamurthy S.; Kube D.; Kumar K.; Kumar P.; Kumar S.; Kumar Y.; Kundra R.; Kubler K.; Kuppers R.; Lagergren J.; Lai P.H.; Laird P.W.; Lakhani S.R.; Lalansingh C.M.; Lalonde E.; Lamaze F.C.; Lambert A.; Lander E.; Landgraf P.; Landoni L.; Langerod A.; Lanzos A.; Larsimont D.; Larsson E.; Lathrop M.; Lau L.M.S.; Lawerenz C.; Lawlor R.T.; Lawrence M.S.; Lazar A.J.; Lazic A.M.; Le X.; Lee D.; Lee D.; Lee E.A.; Lee H.J.; Lee J.J.-K.; Lee J.-Y.; Lee J.; Lee M.T.M.; Lee-Six H.; Lehmann K.-V.; Lehrach H.; Lenze D.; Leonard C.R.; Leongamornlert D.A.; Leshchiner I.; Letourneau L.; Letunic I.; Levine D.A.; Lewis L.; Ley T.; Li C.; Li C.H.; Li H.I.; Li J.; Li L.; Li S.; Li S.; Li X.; Li X.; Li X.; Li Y.; Liang H.; Liang S.-B.; Lichter P.; Lin P.; Lin Z.; Linehan W.M.; Lingjaerde O.C.; Liu D.; Liu E.M.; Liu F.-F.F.; Liu F.; Liu J.; Liu X.; Livingstone J.; Livitz D.; Livni N.; Lochovsky L.; Loeffler M.; Long G.V.; Lopez-Guillermo A.; Lou S.; Louis D.N.; Lovat L.B.; Lu Y.; Lu Y.-J.; Lu Y.; Luchini C.; Lungu I.; Luo X.; Luxton H.J.; Lynch A.G.; Lype L.; Lopez C.; Lopez-Otin C.; Ma E.Z.; Ma Y.; MacGrogan G.; MacRae S.; Macintyre G.; Madsen T.; Maejima K.; Mafficini A.; Maglinte D.T.; Maitra A.; Majumder P.P.; Malcovati L.; Malikic S.; Malleo G.; Mann G.J.; Mantovani-Loffler L.; Marchal K.; Marchegiani G.; Mardis E.R.; Margolin A.A.; Marin M.G.; Markowetz F.; Markowski J.; Marks J.; Marques-Bonet T.; Marra M.A.; Marsden L.; Martens J.W.M.; Martin S.; Martin-Subero J.I.; Martincorena I.; Martinez-Fundichely A.; Maruvka Y.E.; Mashl R.J.; Massie C.E.; Matthew T.J.; Matthews L.; Mayer E.; Mayes S.; Mayo M.; Mbabaali F.; McCune K.; McDermott U.; McGillivray P.D.; McLellan M.D.; McPherson J.D.; McPherson J.R.; McPherson T.A.; Meier S.R.; Meng A.; Meng S.; Menzies A.; Merrett N.D.; Merson S.; Meyerson M.; Meyerson W.; Mieczkowski P.A.; Mihaiescu G.L.; Mijalkovic S.; Mikkelsen T.; Milella M.; Mileshkin L.; Miller C.A.; Miller D.K.; Miller J.K.; Mills G.B.; Milovanovic A.; Minner S.; Miotto M.; Arnau G.M.; Mirabello L.; Mitchell C.; Mitchell T.J.; Miyano S.; Miyoshi N.; Mizuno S.; Molnar-Gabor F.; Moore M.J.; Moore R.A.; Morganella S.; Morris Q.D.; Morrison C.; Mose L.E.; Moser C.D.; Muinos F.; Mularoni L.; Mungall A.J.; Mungall K.; Musgrove E.A.; Mustonen V.; Mutch D.; Muyas F.; Muzny D.M.; Munoz A.; Myers J.; Myklebost O.; Moller P.; Nagae G.; Nagrial A.M.; Nahal-Bose H.K.; Nakagama H.; Nakagawa H.; Nakamura H.; Nakamura T.; Nakano K.; Nandi T.; Nangalia J.; Nastic M.; Navarro A.; Navarro F.C.P.; Neal D.E.; Nettekoven G.; Newell F.; Newhouse S.J.; Newton Y.; Ng A.W.T.; Ng A.; Nicholson J.; Nicol D.; Nie Y.; Nielsen G.P.; Nielsen M.M.; Nik-Zainal S.; Noble M.S.; Nones K.; Northcott P.A.; Notta F.; O'Connor B.D.; O'Donnell P.; O'Donovan M.; O'Meara S.; O'Neill B.P.; O'Neill J.R.; Ocana D.; Ochoa A.; Oesper L.; Ogden C.; Ohdan H.; Ohi K.; Ohno-Machado L.; Oien K.A.; Ojesina A.I.; Ojima H.; Okusaka T.; Omberg L.; Ong C.K.; Ossowski S.; Ott G.; Ouellette B.F.F.; P'ng C.; Paczkowska M.; Paiella S.; Pairojkul C.; Pajic M.; Pan-Hammarstrom Q.; Papaemmanuil E.; Papatheodorou I.; Paramasivam N.; Park J.W.; Park J.-W.; Park K.; Park K.; Park P.J.; Parker J.S.; Parsons S.L.; Pass H.; Pasternack D.; Pastore A.; Patch A.-M.; Pauporte I.; Pea A.; Pearson J.V.; Pedamallu C.S.; Pederzoli P.; Peifer M.; Pennell N.A.; Perou C.M.; Perry M.D.; Petersen G.M.; Peto M.; Petrelli N.; Petryszak R.; Pfister S.M.; Phillips M.; Pich O.; Pickett H.A.; Pihl T.D.; Pillay N.; Pinder S.; Pinese M.; Pinho A.V.; Pitkanen E.; Pivot X.; Pineiro-Yanez E.; Planko L.; Plass C.; Polak P.; Pons T.; Popescu I.; Potapova O.; Prasad A.; Preston S.R.; Prinz M.; Pritchard A.L.; Prokopec S.D.; Provenzano E.; Puente X.S.; Puig S.; Puiggros M.; Pulido-Tamayo S.; Pupo G.M.; Purdie C.A.; Quinn M.C.; Rabionet R.; Rader J.S.; Radlwimmer B.; Radovic P.; Raeder B.; Raine K.M.; Ramakrishna M.; Ramakrishnan K.; Ramalingam S.; Raphael B.J.; Rathmell W.K.; Rausch T.; Reifenberger G.; Reimand J.; Reis-Filho J.; Reuter V.; Reyes-Salazar I.; Reyna M.A.; Reynolds S.M.; Rheinbay E.; Riazalhosseini Y.; Richardson A.L.; Richter J.; Ringel M.; Ringner M.; Rino Y.; Rippe K.; Roach J.; Roberts L.R.; Roberts N.D.; Roberts S.A.; Robertson A.G.; Robertson A.J.; Rodriguez J.B.; Rodriguez-Martin B.; Rodriguez-Gonzalez F.G.; Roehrl M.H.A.; Rohde M.; Rokutan H.; Romieu G.; Rooman I.; Roques T.; Rosebrock D.; Rosenberg M.; Rosenstiel P.C.; Rosenwald A.; Rowe E.W.; Royo R.; Rozen S.G.; Rubanova Y.; Rubin M.A.; Rubio-Perez C.; Rudneva V.A.; Rusev B.C.; Ruzzenente A.; Ratsch G.; Sabarinathan R.; Sabelnykova V.Y.; Sadeghi S.; Sahinalp S.C.; Saini N.; Saito-Adachi M.; Saksena G.; Salcedo A.; Salgado R.; Salichos L.; Sallari R.; Saller C.; Salvia R.; Sam M.; Samra J.S.; Sanchez-Vega F.; Sanders G.; Sarin R.; Sarrafi I.; Sasaki-Oku A.; Sauer T.; Sauter G.; Saw R.P.M.; Scardoni M.; Scarlett C.J.; Scarpa A.; Scelo G.; Schadendorf D.; Schein J.E.; Schilhabel M.B.; Schlesner M.; Schlomm T.; Schmidt H.K.; Schramm S.-J.; Schreiber S.; Schultz N.; Schumacher S.E.; Schwarz R.F.; Scolyer R.A.; Scott D.; Scully R.; Seethala R.; Segre A.V.; Selander I.; Semple C.A.; Senbabaoglu Y.; Sengupta S.; Sereni E.; Serra S.; Sgroi D.C.; Shah N.C.; Shahabi S.; Shang C.A.; Shang P.; Shapira O.; Shelton T.; Shen C.; Shen H.; Shepherd R.; Shi R.; Shi Y.; Shiah Y.-J.; Shibata T.; Shih J.; Shimizu E.; Shimizu K.; Shin S.J.; Shiraishi Y.; Shmaya T.; Shmulevich I.; Shorser S.I.; Short C.; Shrestha R.; Shringarpure S.S.; Shriver C.; Shuai S.; Sidiropoulos N.; Siebert R.; Sieuwerts A.M.; Sieverling L.; Signoretti S.; Sikora K.O.; Simbolo M.; Simon R.; Simons J.V.; Simpson J.T.; Simpson P.T.; Singer S.; Sinnott-Armstrong N.; Sipahimalani P.; Skelly T.J.; Smid M.; Smith J.; Smith-McCune K.; Socci N.D.; Sofia H.J.; Soloway M.G.; Song L.; Sood A.K.; Sothi S.; Sotiriou C.; Soulette C.M.; Span P.N.; Spellman P.T.; Sperandio N.; Spillane A.J.; Spiro O.; Spring J.; Staaf J.; Stadler P.F.; Staib P.; Stark S.G.; Stebbings L.; Stefansson O.A.; Stegle O.; Stenhouse A.; Stewart C.; Stilgenbauer S.; Stobbe M.D.; Stratton M.R.; Stretch J.R.; Struck A.J.; Stuart J.M.; Stunnenberg H.G.; Su H.; Su X.; Sun R.X.; Sungalee S.; Susak H.; Suzuki A.; Sweep F.; Szczepanowski M.; Sultmann H.; Yugawa T.; Tam A.; Tamborero D.; Tan B.K.T.; Tan D.; Tan P.; Tanaka H.; Taniguchi H.; Tanskanen T.J.; Tarabichi M.; Tarnuzzer R.; Tarpey P.; Taschuk M.L.; Tatsuno K.; Tavare S.; Taylor D.F.; Taylor-Weiner A.; Teague J.W.; Teh B.T.; Tembe V.; Temes J.; Thai K.; Thayer S.P.; Thiessen N.; Thomas G.; Thomas S.; Thompson A.; Thompson A.M.; Thompson J.F.F.; Thompson R.H.; Thorne H.; Thorne L.B.; Thorogood A.; Tiao G.; Tijanic N.; Timms L.E.; Tirabosco R.; Tojo M.; Tommasi S.; Toon C.W.; Toprak U.H.; Torrents D.; Tortora G.; Tost J.; Totoki Y.; Townend D.; Traficante N.; Treilleux I.; Trotta J.-R.; Trumper L.H.P.; Tsao M.; Tsunoda T.; Tubio J.M.C.; Tucker O.; Turkington R.; Turner D.J.; Tutt A.; Ueno M.; Ueno N.T.; Umbricht C.; Umer H.M.; Underwood T.J.; Urban L.; Urushidate T.; Ushiku T.; Uuskula-Reimand L.; Van Den Berg D.J.; Van Laere S.; Van Loo P.; Van Meir E.G.; Van den Eynden G.G.; Van der Kwast T.; Vasudev N.; Vedururu R.; Veluvolu U.; Vembu S.; Verbeke L.P.C.; Vermeulen P.; Verrill C.; Viari A.; Vicente D.; Vicentini C.; VijayRaghavan K.; Viksna J.; Vilain R.E.; Villasante I.; Vincent-Salomon A.; Visakorpi T.; Voet D.; Vyas P.; Vazquez-Garcia I.; Waddell N.M.; Waddell N.; Wadelius C.; Wadi L.; Wagener R.; Wala J.A.; Wang J.; Wang J.; Wang L.; Wang Q.; Wang W.; Wang Y.; Wang Z.; Waring P.M.; Warnatz H.-J.; Warrell J.; Warren A.Y.; Waszak S.M.; Wedge D.C.; Weichenhan D.; Weinberger P.; Weinstein J.N.; Weischenfeldt J.; Weisenberger D.J.; Welch I.; Wendl M.C.; Werner J.; Whalley J.P.; Wheeler D.A.; Whitaker H.C.; Wigle D.; Wilkerson M.D.; Williams A.; Wilmott J.S.; Wilson G.W.; Wilson J.M.; Wilson R.K.; Winterhoff B.; Wintersinger J.A.; Wiznerowicz M.; Wolf S.; Wong B.H.; Wong T.; Wong W.; Woo Y.; Wood S.; Wouters B.G.; Wright A.J.; Wright D.W.; Wright M.H.; Wu C.-L.; Wu D.-Y.; Wu J.; Wu K.; Wu Y.; Wu Z.; Xi L.; Xia T.; Xiang Q.; Xiao X.; Xing R.; Xiong H.; Xu Q.; Xu Y.; Xue H.; Yachida S.; Yakneen S.; Yamaguchi R.; Yamaguchi T.N.; Yamamoto M.; Yamamoto S.; Yamaue H.; Yang F.; Yang H.; Yang J.Y.; Yang L.; Yang L.; Yang S.; Yang T.-P.; Yang Y.; Yao X.; Yaspo M.-L.; Yates L.; Yau C.; Ye C.; Ye K.; Yellapantula V.D.; Yoon C.J.; Yoon S.-S.; Yousif F.; Yu K.; Yu W.; Yu Y.; Yuan K.; Yuan Y.; Yuen D.; Yung C.K.; Zaikova O.; Zamora J.; Zapatka M.; Zenklusen J.C.; Zenz T.; Zeps N.; Zhang C.-Z.; Zhang F.; Zhang H.; Zhang H.; Zhang H.; Zhang J.; Zhang J.; Zhang J.; Zhang X.; Zhang X.; Zhang Y.; Zhang Z.; Zhao Z.; Zheng L.; Zheng X.; Zhou W.; Zhou Y.; Zhu B.; Zhu H.; Zhu J.; Zhu S.; Zou L.; Zou X.; deFazio A.; van As N.; van Deurzen C.H.M.; van de Vijver M.J.; van't Veer L.; von Mering C.
24/03/2026 09:46:32
Authors: 335 111 RIVER ST, HOBOKEN 07030-5774, NJ USA; 2-s2.0-85112378393 33739461
Journal: Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy
Published: cc-by
eng
Volume: Rigolin G.M.; Cavazzini F.; Piciocchi A.; Arena V.; Visentin A.; Reda G.; Zamprogna G.; Cibien F.; Vitagliano O.; Coscia M.; Farina L.; Gaidano G.; Murru R.; Varettoni M.; Paolini R.; Sportoletti P.; Pietrasanta D.; Molinari A.L.; Quaglia F.M.; Laurenti L.; Marasca R.; Marchetti M.; Mauro F.R.; Crea E.; Vignetti M.; Gentile M.; Montillo M.; Foa R.; Cuneo A.; Chiarenza A.; Perbellini O.; Mannina D.; Sancetta R.; Olivieri A.; Molica S.; Pane F.; Patti C.; Iliariucci F.; Gozzetti A.; Califano C.; Galieni P.; Augello A.F.; Vallisa D.; Cura F.; Frustaci A.M.; Fazi P.; Trentin L.; Ferrara F. Pages: Rigolin||Cavazzini||Piciocchi||Arena||Visentin||Reda||Zamprogna||Cibien||Vitagliano||Coscia||Farina||Gaidano||Murru||Varettoni||Paolini||Sportoletti||Pietrasanta||Molinari||Quaglia||Laurenti||Marasca||Marchetti||Mauro||Crea||Vignetti||Gentile||Montillo||Foà||Cuneo||Chiarenza||Perbellini||Mannina||Sancetta||Olivieri||Molica||Pane||Patti||Iliariucci||Gozzetti||Califano||Galieni||Augello||Vallisa||Cura||Frustaci||Fazi||Trentin||Ferrara-Because the efficacy of new drugs reported in trials may not translate into similar results when used in the real-life, we analyzed the efficacy of idelalisib and rituximab (IR) in 149 patients with relapsed/refractory chronic lymphocytic leukemia treated at 34 GIMEMA centers. Median progression-free survival (PFS) and overall survival were 22.9 and 44.5 months, respectively; performance status (PS) ≥2 and ≥3 previous lines of therapy were associated with shorter PFS and overall survival (OS). 48% of patients were on treatment at 12 months; the experience of the centers (≥5 treated patients) and PS 0–1 were associated with a significantly longer treatment duration (p = 0.015 and p = 0.002, respectively). TP53 disruption had no prognostic significance. The overall response rate to subsequent treatment was 49.2%, with median OS of 15.5 months and not reached in patients who discontinued, respectively, for progression and for toxicity (p < 0.01). Treatment breaks ≥14 days were recorded in 96% of patients and adverse events mirrored those reported in trials. In conclusion, this real-life analysis showed that IR treatment duration was longer at experienced centers, that the ECOG PS and ≥3 lines of previous therapy are strong prognostic factor and that the overall outcome with this regimen was superimposable to that reported in a randomized trial.
05/05/2026 15:05:51
Authors: ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND; 2-s2.0-85103480336
Journal: Overview of prognostic systems for hepatocellular carcinoma and ITA.LI.CA external validation of MESH and CNLC classifications
Published: cc-by
DOI: 7
eng
Volume: Vitale A.; Farinati F.; Finotti M.; Di Renzo C.; Brancaccio G.; Piscaglia F.; Cabibbo G.; Caturelli E.; Missale G.; Marra F.; Sacco R.; Giannini E.G.; Trevisani F.; Cillo U.; Bhoori S.; Borzio M.; Burra P.; Casadei Gardini A.; Carrai P.; Conti F.; Cozzolongo R.; Cucchetti A.; D'ambrosio R.; Dell'unto C.; De Matthaeis N.; Di Costanzo G.G.; Di Sandro S.; Famularo S.; Foschi F.G.; Fucilli F.; Galati G.; Gambato M.; Gasbarrini A.; Giuliante F.; Ghinolfi D.; Grieco A.; Gruttadauria S.; Guarino M.; Iavarone M.; Kostandini A.; Lai Q.; Lenci I.; Levi Sandri G.V.; Losito F.; Lupo L.G.; Marasco G.; Manzia T.M.; Mazzocato S.; Masarone M.; Melandro F.; Mescoli C.; Miele L.; Morisco F.; Muley M.; Nicolini D.; Pagano D.; Persico M.; Pompili M.; Ponziani F.R.; Pravisani R.; Rapaccini G.L.; Rendina M.; Renzulli M.; Romano F.; Rossi M.; Rreka E.; Russo F.P.; Sangiovanni A.; Sessa A.; Simonetti N.; Sposito C.; Tortora R.; Vigano L.; Vigano M.; Villa E.; Vincenzi V.; Violi P.; Azzaroli F.; Brunetto M.R.; Di Marco A.; Gasbarrini A.; Foschi F.G.; Guarino M.; Masotto A.; Mega A.; Morisco F.; Nardone G.; Oliveri F.; Raimondo G.; Rapaccini G.L.; Svegliati Baroni G.; Vidili G.; Zoli M.
09/05/2026 04:50:40
Authors: 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND; 2-s2.0-85116918740
Journal: Italy||Italy||Italy||Italy||Italy||Italy
Published: 15470
eng
Volume: Muffato V.; Feraco T.; Miola L.; Tortora C.; Pazzaglia F.; Meneghetti C. Pages: Muffato||Feraco||Miola||Tortora||Pazzaglia||Meneghetti-Finding the shortest path to a destination is a refined navigation ability little explored as yet in familiar environments. The present study examined this ability when walking or describing the path, and how performance relates to individual differences. Sixty-seven undergraduates familiar with the area around their campus were asked to find the shortest path to a destination by walking there or describing it in writing. Several visuospatial tasks and questionnaires were administered. It emerged that shortest path finding performance was supported by familiarity and sense of direction. After accounting for these individual factors, participants performed better when walking than when describing a path. Overall, the results showed that retrieving spatial knowledge about familiar environments relates to individual differences and recall condition, walking a path being easier than describing it.
25/04/2026 04:39:52
Authors: 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA; 2-s2.0-85114467298
Journal: Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy
Published: cc-by
eng
Volume: Daniele G.; Schettino C.; Arenare L.; Bilancia D.; Farinati F.; Federico P.; Tamberi S.; Crivellari G.; Barni S.; Tortora R.; Izzo F.; Frassoldati A.; Cavanna L.; Mucciarini C.; Bolondi L.; Dinota A.; Pelizzaro F.; Piccirillo M.C.; Gargiulo P.; Maio M.D.; Gallo C.; Perrone F.; Daniele B. Pages: Daniele||Schettino||Arenare||Bilancia||Farinati||Federico||Tamberi||Crivellari||Barni||Tortora||Izzo||Frassoldati||Cavanna||Mucciarini||Bolondi||Dinota||Pelizzaro||Piccirillo||Gargiulo||Maio||Gallo||Perrone||Daniele-Aim: Only patients with good liver function {[Child-Pugh (CP)] A class} were eligible for trials testing sorafenib as first-line treatment of hepatocellular carcinoma (HCC); nevertheless, the drug was authorized without restrictions based on liver function. Therefore, we planned to test sorafenib efficacy and safety in patients with HCC and deteriorated liver function (CP-B). Methods: This was an open-label, multicenter, randomized phase 3 trial. Patients with HCC, no previous systemic therapy, and CP-B score 7-9 were assigned 1:1 to best supportive care alone (control arm) or with standard dose sorafenib (experimental arm). Overall survival (OS) was the primary endpoint. To detect a 0.70 HR of death, with 80% power, and two-tailed α error 0.05, 234 events were required. The study closed prematurely because of slow accrual. Descriptive analyses are reported. Results: From 2012 to 2017, 13 Italian centers randomized 35 patients. In total, 28 deaths were recorded, 12 without and 16 with sorafenib; median OS was 4.9 (95%CI: 1.2-5.6) and 3.5 months (95%CI: 1.3-5.3), respectively. At least one severe adverse event was reported in 2/15 (13.3%) without and 9/17 (52.9%) patients with sorafenib. Conclusions: This trial failed its planned enrolment goal, showing the difficulty in performing clinical trials with drugs already registered with a label broader than what available evidence supports.
29/04/2026 03:07:13
Authors: ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND; 2-s2.0-85108681688
Journal: Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy
Published: cc-by
eng
Volume: Meacci E.; Nachira D.; Zanfrini E.; Evangelista J.; Triumbari E.K.A.; Congedo M.T.; Petracca Ciavarella L.; Chiappetta M.; Vita M.L.; Schinzari G.; Rossi E.; Tortora G.; Lucchi M.; Ambrogi M.; Calabro F.; Petrella F.; Spaggiari L.; Mammana M.; Madrid A.L.; Rea F.; Tabacco D.; Margaritora S. Pages: Meacci||Nachira||Zanfrini||Evangelista||Triumbari||Congedo||Petracca Ciavarella||Chiappetta||Vita||Schinzari||Rossi||Tortora||Lucchi||Ambrogi||Calabrò||Petrella||Spaggiari||Mammana||Madrid||Rea||Tabacco||Margaritora-In this paper we aimed to address the role of pulmonary metastasectomy (PM) in patients affected by Lung Metastases (LM) from Renal Cell Carcinoma (RCC) and to analyse prognostic factors affecting overall survival (OS), disease-free interval (DFI) between primary RCC and first LM, and disease-free survival (DFS) after PM and before lung recurrence. Medical records of 210 patients who underwent PM from RCC in 4 Italian Thoracic Centres, from January 2000 to September 2019, were collected and analysed. All patients underwent RCC resection before lung surgery. The main RCC histology was clear cells (188, 89.5%). The 5-and 10-year OS from the first lung operation were 60% and 34%, respectively. LM synchronous with RCC (p = 0.01) and (Karnofsky Performance Status Scale) KPSS < 80% (p < 0.001) negatively influenced OS. Five-and 10-year DFI were 54% and 28%, respectively. The main factors negatively influencing DFI were: male gender (p = 0.039), KPSS < 80% (p = 0.009) and lactate dehydrogenase > 1.5 times 140 U/L (p = 0.001). Five-and 10-year disease-free survival were 54% and 28%, respectively; multiple LM (p = 0.036), KPSS < 80% (p = 0.001) and histology of RCC other than clear cells negatively influenced disease-free survival. Conclusions: patients with KPSS > 80%, single metachronous LM with a long DFI from RCC diagnosis, and clear cell histology, benefit from pulmonary metastasectomy.
19/04/2026 08:27:21
Authors: MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND; 2-s2.0-85106956473 34072888
Journal: Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy
Published: cc-by
eng
Volume: Brun P.; Zamuner A.; Battocchio C.; Cassari L.; Todesco M.; Graziani V.; Iucci G.; Marsotto M.; Tortora L.; Secchi V.; Dettin M. Pages: Brun||Zamuner||Battocchio||Cassari||Todesco||Graziani||Iucci||Marsotto||Tortora||Secchi||Dettin-Hybrid biomaterials allow for the improvement of the biological properties of materials and have been successfully used for implantology in medical applications. The covalent and selective functionalization of materials with bioactive peptides provides favorable results in tissue engineering by supporting cell attachment to the biomaterial through biochemical cues and interaction with membrane receptors. Since the functionalization with bioactive peptides may alter the chemical and physical properties of the biomaterials, in this study we characterized the biological responses of differently functionalized chitosan analogs. Chitosan analogs were produced through the reaction of GRGDSPK (RGD) or FRHRNRKGY (HVP) sequences, both carrying an aldehyde-terminal group, to chitosan. The bio-functionalized polysaccharides, pure or “diluted” with chitosan, were chemically characterized in depth and evaluated for their antimicrobial activities and biocompatibility toward human primary osteoblast cells. The results obtained indicate that the bio-functionalization of chi-tosan increases human-osteoblast adhesion (p <0.005) and proliferation (p < 0.005) as compared with chitosan. Overall, the 1:1 mixture of HVP functionalized-chitosan:chitosan is the best compromise between preserving the antibacterial properties of the material and supporting osteoblast differentiation and calcium deposition (p < 0.005 vs. RGD). In conclusion, our results reported that a selected concentration of HVP supported the biomimetic potential of functionalized chitosan better than RGD and preserved the antibacterial properties of chitosan.
08/05/2026 06:27:13
Authors: MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND; 2-s2.0-85112011075
Journal: Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy||Italy
Published: cc-by
eng
Volume: Tortora M.; Tranfa M.; D'Elia A.C.; Pontillo G.; Petracca M.; Bozzao A.; Caranci F.; Cervo A.; Cosottini M.; Falini A.; Longo M.; Manara R.; Muto M.; Porcu M.; Roccatagliata L.; Todeschini A.; Saba L.; Brunetti A.; Cocozza S.; Elefante A. Pages: Tortora||Tranfa||D’Elia||Pontillo||Petracca||Bozzao||Caranci||Cervo||Cosottini||Falini||Longo||Manara||Muto||Porcu||Roccatagliata||Todeschini||Saba||Brunetti||Cocozza||Elefante-(1) Although guidelines about the use of MRI sequences for Multiple Sclerosis (MS) diagnosis and follow-up are available, variability in acquisition protocols is not uncommon in everyday clinical practice. The aim of this study was to evaluate the real-world application of MS imaging guidelines in different settings to clarify the level of adherence to these guidelines. (2) Via an on-line anonymous survey, neuroradiologists (NR) were asked about MRI protocols and parameters routinely acquired when MS patients are evaluated in their center, both at diagnosis and followup. Furthermore, data about report content and personal opinions about emerging neuroimaging markers were also retrieved. (3) A total of 46 participants were included, mostly working in a hospital or university hospital (80.4%) and with more than 10 years of experience (47.9%). We found a relatively good adherence to the suggested MRI protocols regarding the use of T2-weighted sequences, although almost 10% of the participants routinely acquired 2D sequences with a slice thickness superior to 3 mm. On the other hand, a wider degree of heterogeneity was found regarding gadolinium administration, almost routinely performed at follow-up examination (87.0% of cases) in contrast with the current guidelines, as well as a low use of a standardized reporting system (17.4% of cases). (4) Although the MS community is getting closer to a standardization of MRI protocols, there is still a relatively wide heterogeneity among NR, with particular reference to contrast administration, which must be overcome to guarantee an adequate quality of patients’ care in MS.
AREA MIN. 02 – Scienze fisiche||AREA MIN. 02 – Scienze fisiche – 15-19 March, 2021
Authors: AREA MIN. 02 - Scienze fisiche
Published: 1778375012223
AREA MIN. 02 – Scienze fisiche||AREA MIN. 02 – Scienze fisiche – 15-19 March, 2021
Authors: AREA MIN. 02 - Scienze fisiche
Published: 1778375013225