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To describe results of training and 1-year follow-up of brain-communication in a larger group of early and middle stage amyotrophic lateral sclerosis (ALS) patients using a P300-based brain-computer interface (BCI), and to investigate the relationship between clinical status, age and BCI performance. A group of 21 ALS patients were tested with a BCI-system using two-dimensional cursor movements. A four choice visual paradigm was employed to training and test the brain-communication abilities. The task consisted of reaching with the cursor one out of four icons representing four basic needs. Five patients performed a follow-up test 1 year later. The clinical severity in all patients were assessed with a battery of clinical tests. A comparable control group of nine healthy subjects was employed to investigate performance differences. Nineteen patients and nine healthy subjects were able to achieve good and excellent cursor movements’ control, acquiring at least communication abilities above chance level; during follow-up the patients maintained their BCI-skill. We found mild cognitive impairments in the ALS group which may be attributed to motor deficiencies, while no relevant correlation has been found between clinical data and BCI performance. A positive correlation between age and the BCI-skill in patients was found. Time since training acquisition and clinical status did not affect the patients brain-communication skill at early and middle stage of the disease. A brain-communication tool can be used in most ALS patients at early and middle stage of the disease before entering the locked-in stage. © 2009 Silvoni, Volpato, Cavinato, Marchetti, Priftis, Merico, Tonin, Koutsikos, Beverina and Piccione.

Authors: publisher P300-based brain-computer interface communication: Evaluation and follow-up in amyotrophic lateral sclerosis; 2009 Dept Gen Psychol

Journal: cc-by

Published: Silvoni, S; Volpato, C; Cavinato, M; Marchetti, M; Priftis, K; Merico, A; Tonin, P; Koutsikos, K; Beverina, F; Piccione, F;

DOI: true

WOS.SCI

Volume: https://www.frontiersin.org/articles/10.3389/neuro.20.001.2009/pdf Pages: 103061402||103061402-gold

Keywords: 2009

Zattra E.; Tonin E.; Fortina A.B.; Pigozzi B.; Alaibac M.

Authors: Clinical tip: Use of a manual dermatoscope with a compact digital camera in a pigmented lesion clinic; 2009 Melanoma Unit; Dermatol Unit; Melanoma Unit

Journal: Clinical tip: use of a manual dermatoscope with a compact digital camera in a pigmented lesion clinic

Published: Zattra, E; Tonin, E; Fortina, AB; Pigozzi, B; Alaibac, M;

DOI: false

WOS.SCI

Volume: Zattra||Tonin||Fortina||Pigozzi||Alaibac Pages: 103061702||107937314||100279593||107937314||103061702-closed

Keywords: 2009

We reveal nonmanifest gauge and SO(1,5) Lorentz symmetries in the Lagrangian description of a six-dimensional free chiral field derived from the Bagger-Lambert-Gustavsson model in and make this formulation covariant with the use of a triplet of auxiliary scalar fields. We consider the coupling of this self-dual construction to gravity and its supersymmetrization. In the case of the nonlinear model of we solve the equations of motion of the gauge field, prove that its nonlinear field strength is self-dual and find a gauge-covariant form of the nonlinear action. Issues of the relation of this model to the known formulations of the M5-brane worldvolume theory are discussed. © 2009 The American Physical Society.

Authors: repository Bagger-Lambert-Gustavsson-motivated Lagrangian formulation for the chiral two-form gauge field in D=6 and M5-branes; 2009 Dipartimento Fis Galileo Galilei; Sez Padova; Dipartimento Fis Galileo Galilei

Journal: Bagger-Lambert-Gustavsson-motivated Lagrangian formulation for the chiral two-form gauge field in D=6 and M5-branes

Published: Pasti, P; Samsonov, I; Sorokin, D; Tonin, M;

DOI: false

WOS.SCI

Volume: https://arxiv.org/pdf/0907.4596 Pages: 120600194||104217541||120600194||120600194-green

Keywords: 2009

AREA MIN. 06 – Scienze mediche – 2009

Authors: 2009 Unit Dermatol; Melanoma Unit; Dept Pediat; Unit Dermatol

Journal: Use of a manual dermatoscope with a compact digital camera in skin cancer triage

Published: Zattra, E; Tonin, E; Belloni-Fortina, A; Pigozzi, B; Alaibac, M;

DOI: English

WOS.SCI

Objective: Telerehabilitation enables a remotely controlled programme to be used to treat motor deficits in post-stroke patients. The effects of this telerehabilitation approach were compared with traditional motor rehabilitation methods. Design: Randomized single-blind controlled trial. Patients: A total of 36 patients with mild arm motor impairments due to ischaemic stroke in the region of the middle cerebral artery. Methods: The experimental treatment was a virtual reality-based system delivered via the Internet, which provided motor tasks to the patients from a remote rehabilitation facility. The control group underwent traditional physical therapy for the upper limb. Both treatments were of 4 weeks duration. All patients were assessed one month prior to therapy, at the commencement and termination of therapies and one month post-therapy, with the Fugl-Meyer Upper Extremity, the ABILHAND and the Ashworth scales. Results: Both rehabilitative therapies significantly improved all outcome scores after treatment, but only the Fugl-Meyer Upper Extremity scale showed differences in the comparison between groups. Conclusion: Both strategies were effective, but the experimental approach induced better outcomes in motor performance. These results may favour early discharge from hospital sustained by a telerehabilitation programme, with potential beneficial effects on the use of available resources. © 2009 The Authors.

Authors: publisher Exercises for paretic upper limb after stroke: A combined virtual-reality and telemedicine approach; 2009 Dept Rehabil; Dept Rehabil; Dept Neurosci; Dept Stat

Journal: EXERCISES FOR PARETIC UPPER LIMB AFTER STROKE: A COMBINED VIRTUAL-REALITY AND TELEMEDICINE APPROACH

Published: Piron, L; Turolla, A; Agostini, M; Zucconi, C; Cortese, F; Zampolini, M; Zannini, M; Dam, M; Ventura, L; Battauz, M; Tonin, P;

DOI: true

WOS.SCI

Volume: Piron||Turolla||Agostini||Zucconi||Cortese||Zampolini||Zannini||Dam||Ventura||Battauz||Tonin Pages: 105620658||105620284||107933855||103061186||113623886-gold

Keywords: 2009

Belloni-Fortina A.; Piaserico S.; Tonin E.; Alaibac M.

Authors: Melanoma and immunosuppression; 2009 Unit Dermatol; Unit Dermatol; NCI

Journal: Melanoma and Immunosuppression

Published: Belloni-Fortina, A; Piaserico, S; Tonin, E; Alaibac, M;

DOI: false

WOS.SCI

Volume: Belloni-Fortina||Piaserico||Tonin||Alaibac Pages: 103061702||103061702||108397459||103061702-closed

Keywords: 2008

Background: Evoked potentials allow one to assess functional integrity of sensory pathways projecting to primary sensory cortices and event-related potentials assess higher order cortical functions associated with stimulus detection and decision-making. Evoked and event-related potentials have been used to predict emergence from coma. This study aimed to determine whether they can help prediction of consciousness recovery in post-traumatic vegetative state (VS). Methods: Thirty-four patients in post-traumatic VS were assessed clinically and neurophysiologically at 2-3 months after injury and followed up to 1 year. Patients were assessed with the Disability Rating Scale (DRS) and with electroencephalogram (EEG), brainstem auditory (BAEP) and somatosensory evoked potentials (SEP) and P300. Demographic, clinical and neurophysiological measures were analysed by descriptive and logistic regression techniques. Results: At 1 year from injury, 26 patients (76%) had recovered consciousness and eight patients (24%) had not. In univariate analyses, a detectable P300, a reactive EEG and lower DRS scores were found at entry assessment more frequently (p 0.05) in patients who later recovered consciousness than in those who did not. Logistic regression analysis revealed that P300 was the only factor contributing to prediction of conscious recovery with an area under the ROC curve of 0.94 (95% CI, 0.80-0.99). Conclusions: P300 is a strong predictor of conscious recovery in VS. © 2009 Informa Healthcare Ltd.

Authors: Post-acute P300 predicts recovery of consciousness from traumatic vegetative state; 2009 Ist Cura San Camillo; Dipartimento Farmacol & Anestesiol; Ist Cura San Camillo

Journal: Post-acute P300 predicts recovery of consciousness from traumatic vegetative state

Published: Cavinato, M; Freo, U; Ori, C; Zorzi, M; Tonin, P; Piccione, F; Merico, A;

DOI: false

WOS.SCI

Volume: Cavinato||Freo||Ori||Zorzi||Tonin||Piccione||Merico Pages: 123085330||103061708||103061708||123085330||123085330||123085330-closed

Keywords: 2009

Aims: To assess the role of type 2 diabetes as a risk factor for cognitive decline among elderly people. Methods: Analyses were carried out on data from the Italian Longitudinal Study on Aging, a study on 5,632 subjects aged 65-84 years, with baseline in 1992 and follow-ups in 1996 and 2000. Results:At baseline, diabetic women had significantly worse scores on all cognitive tests compared to nondiabetic women, but did not show worsening over time, whereas men with diabetes did not show worse scores on cognitive tests at baseline compared to nondiabetic males; however, diabetes in men was associated with a risk of cognitive decline over time, particularly in attention. Higher levels of HbA1c were associated with poorer performance on memory tests at follow-up in both sexes. Conclusion: The impact of diabetes on cognitive status might differ in older men and women, probably because of a survival effect, with a higher mortality at a younger age among diabetic men. The metabolic and cardiovascular abnormalities associated with diabetes might be responsible for the cognitive decline, at different rates and ages, in men and women. The routine assessment of diabetes complications in the elderly should include cognitive evaluation in both sexes. Copyright © 2008 S. Karger AG.

Authors: Diabetes as a risk factor for cognitive decline in older patients; 2009 Inst Neurosci; Inst Neurosci

Journal: Diabetes as a Risk Factor for Cognitive Decline in Older Patients

Published: Maggi, S; Limongi, F; Noale, M; Romanato, G; Tonin, P; Rozzini, R; Scafato, E; Crepaldi, G;

DOI: false

WOS.SCI

Volume: Maggi||Limongi||Noale||Romanato||Tonin||Rozzini||Scafato||Crepaldi Pages: 104076662||105462489||105462489||105462489||103061168-closed

Keywords: 2009