Publications

Aims: To assess the role of type 2 diabetes as a risk factor for cognitive decline among elderly people. Methods: Analyses were carried out on data from the Italian Longitudinal Study on Aging, a study on 5,632 subjects aged 65-84 years, with baseline in 1992 and follow-ups in 1996 and 2000. Results:At baseline, diabetic women had significantly worse scores on all cognitive tests compared to nondiabetic women, but did not show worsening over time, whereas men with diabetes did not show worse scores on cognitive tests at baseline compared to nondiabetic males; however, diabetes in men was associated with a risk of cognitive decline over time, particularly in attention. Higher levels of HbA1c were associated with poorer performance on memory tests at follow-up in both sexes. Conclusion: The impact of diabetes on cognitive status might differ in older men and women, probably because of a survival effect, with a higher mortality at a younger age among diabetic men. The metabolic and cardiovascular abnormalities associated with diabetes might be responsible for the cognitive decline, at different rates and ages, in men and women. The routine assessment of diabetes complications in the elderly should include cognitive evaluation in both sexes. Copyright © 2008 S. Karger AG.

Authors: Diabetes as a risk factor for cognitive decline in older patients; 2009 Inst Neurosci; Inst Neurosci

Journal: Diabetes as a Risk Factor for Cognitive Decline in Older Patients

Published: Maggi, S; Limongi, F; Noale, M; Romanato, G; Tonin, P; Rozzini, R; Scafato, E; Crepaldi, G;

DOI: false

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Volume: Maggi||Limongi||Noale||Romanato||Tonin||Rozzini||Scafato||Crepaldi Pages: 104076662||105462489||105462489||105462489||103061168-closed

Keywords: 2009

AREA MIN. 06 – Scienze mediche||AREA MIN. 06 – Scienze mediche – 2009

Authors: 2009 Unit Dermatol; Melanoma Unit; Dept Pediat; Unit Dermatol

Journal: Use of a manual dermatoscope with a compact digital camera in skin cancer triage

Published: Zattra, E; Tonin, E; Belloni-Fortina, A; Pigozzi, B; Alaibac, M;

DOI: English

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AREA MIN. 06 – Scienze mediche – 2009

Authors: 2009 Unit Dermatol; Melanoma Unit; Dept Pediat; Unit Dermatol

Journal: Use of a manual dermatoscope with a compact digital camera in skin cancer triage

Published: Zattra, E; Tonin, E; Belloni-Fortina, A; Pigozzi, B; Alaibac, M;

DOI: English

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This paper discusses and evaluates the role of shared control approach in a BCI-based telepresence framework. Driving a mobile device by using human brain signals might improve the quality of life of people suffering from severely physical disabilities. By means of a bidirectional audio/video connection to a robot, the BCI user is able to interact actively with relatives and friends located in different rooms. However, the control of robots through an uncertain channel as a BCI may be complicated and exhaustive. Shared control can facilitate the operation of brain-controlled telepresence robots, as demonstrated by the experimental results reported here. In fact, it allows all subjects to complete a rather complex task, driving the robot in a natural environment along a path with several targets and obstacles, in shorter times and with less number of mental commands. ©2010 IEEE.

Authors: repository The role of shared-control in BCI-based telepresence; 2010 Sch Engn; Sch Engn

Journal: cc-by-nc-nd

Published: Tonin, L; Leeb, R; Tavella, M; Perdikis, S; Millán, JD;

DOI: false

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Volume: https://infoscience.epfl.ch/record/150342/files/smc2010_finalversion.pdf Pages: 109900823||109900823||109900823||109900823||109900823-green

Keywords: 2010

This study intended to describe general personality functioning in patients with a progressive course of multiple sclerosis. 55 consecutive rehabilitation inpatients with progressive course of multiple sclerosis were assessed with a multimethod test battery: the Expanded Disability Status Scale, the Beck Depression Inventory, the State-Trait Anxiety Inventory, the Rosenberg Self-esteem Scale, and the Rorschach Test administered and scored with Comprehensive System. The control group comprised 55 healthy participants with similar sociodemographic characteristics. Specific differences were found for both cognitive and affective aspects, as the patients with progressive course of multiple sclerosis had less positive self-image, less effective mediation processing, and an affective approach to reality. Present data illustrated the usefulness of examining patients with a progressive course of multiple sclerosis to identify abilities and difficulties in cognitive and affective patterns, and support better adaptation to relationships and the environment. © Psychological Reports 2010.

Authors: Personality functioning in patients with a progressive course of multiple sclerosis; 2010 Ist Ricovero & Cura Carattere Sci

Journal: PERSONALITY FUNCTIONING IN PATIENTS WITH A PROGRESSIVE COURSE OF MULTIPLE SCLEROSIS

Published: Lorio, R; Moressa, G; Meneghello, F; Salcuni, S; Stabile, MR; Zennaro, A; Ferro, L; Tonin, P;

DOI: English

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Volume: Lorio||Moressa||Meneghello||Salcuni||Stabile||Zennaro||Ferro||Tonin Pages: 105654090-Dipartimento di Neuroriabilitazione;

Keywords: 2010

Background. Six months after a stroke, the hemiplegic arm often remains compromised. More innovative approaches to motor rehabilitation are needed. Objective. The authors compared a motor learning-based approach in a virtual environment with more conventional upper extremity therapy in a pilot trial. Methods. This prospective, single-blinded, randomized controlled trial compared reinforced feedback in a virtual environment (RFVE; n = 27) with a control intervention (n = 20) of progressive therapy for the affected upper extremity. Both treatments were provided for 4 weeks, 5 days per week, with 1-hour treatment sessions daily. The primary outcomes were the Fugl-Meyer Upper Extremity (F-M UE) and Functional Independence Measure (FIM) scores. Kinematic outcomes included mean duration (MD), mean linear velocity (MLV), and number of submovements to measure the motor performance. Analyses of the primary outcomes were performed per protocol and by intention to treat. Results. F-M UE scores improved significantly in the RFVE group compared with the conventional therapy group (“intention to treat” = 5.10 points, P =.004; ANCOVA = 4.26 points, P <.01). Several of the kinematic parameters improved in the RFVE group (MD, P <.01; MLV, P <.01). FIM improvements did not differ. Conclusions. Both rehabilitation therapies improved arm motor performance and functional activity, but the RFVE therapy induced more robust results in patients exposed to late rehabilitation treatment. © 2010 The Author(s).

Authors: publisher Motor learning principles for rehabilitation: A pilot randomized controlled study in poststroke patients; 2010 IRCCS; IRCCS; Dept Stat

Journal: Motor Learning Principles for Rehabilitation: A Pilot Randomized Controlled Study in Poststroke Patients

Published: Piron, L; Turolla, A; Agostini, M; Zucconi, CS; Ventura, L; Tonin, P; Dam, M;

DOI: false

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Volume: https://journals.sagepub.com/doi/pdf/10.1177/1545968310362672 Pages: 103061186||109486218-bronze

Keywords: 2010

Coenzyme Q10 (CoQ10) deficiency has been associated with an increasing number of clinical phenotypes. Whereas primary CoQ10 defects are related to mutations in ubiquinone biosynthetic genes, which are now being unraveled, and respond well to CoQ10 supplementation, the etiologies, and clinical phenotypes related to secondary deficiencies are largely unknown. The purpose of this multicenter study was to evaluate the frequency of muscle CoQ10 deficiency in a cohort of 76 patients presenting with clinically heterogeneous mitochondrial phenotypes which included myopathy among their clinical features. A reliable diagnostic tool based on HPLC quantification was employed to measure muscle CoQ10 levels. A significant proportion of these patients (28 over 76) displayed CoQ10 deficiency that was clearly secondary in nine patients, who harbored a pathogenic mutation of mitochondrial DNA. This study provides a rationale for future therapeutic trials on the effect of CoQ10 supplementation in patients with mitochondrial diseases presenting with myopathy among clinical features. © 2009 Elsevier B.V. All rights reserved.

Authors: Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy; 2010 Nice Hosp; Dept Pediat; Serv Biochim; Ctr Invest; Neurol Clin; Dept Neurosci; AP HP

Journal: Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy

Published: Sacconi, S; Trevisson, E; Salviati, L; Aymé, S; Rigal, O; Redondo, AG; Mancuso, M; Siciliano, G; Tonin, P; Angelini, C; Auré, K; Lombès, A; Desnuelle, C;

DOI: false

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Volume: Sacconi||Trevisson||Salviati||Aymé||Rigal||Garcia Redondo||Mancuso||Siciliano||Tonin||Angelini||Auré||Lombès||Desnuelle Pages: 120494007||100279593||100279593||103624749||108324026||102307702||108260608||123010475||123010475||120494007-closed

Keywords: 2010

In this paper we present the first results of users with disabilities in mentally controlling a telepresence robot, a rather complex task as the robot is continuously moving and the user must control it for a long period of time (over 6 minutes) to go along the whole path. These two users drove the telepresence robot from their clinic more than 100 km away. Remarkably, although the patients had never visited the location where the telepresence robot was operating, they achieve similar performances to a group of four healthy users who were familiar with the environment. In particular, the experimental results reported in this paper demonstrate the benefits of shared control for brain-controlled telepresence robots. It allows all subjects (including novel BMI subjects as our users with disabilities) to complete a complex task in similar time and with similar number of commands to those required by manual control. © 2011 IEEE.

Authors: Brain-controlled telepresence robot by motor-disabled people; 2011 Sch Engn; Sch Engn

Journal: cc-by-nc-nd

Published: Tonin, L; Carlson, T; Leeb, R; Millán, JD;

DOI: false

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Volume: Tonin||Carlson||Leeb||Del R. Millan Pages: 109068152||109068152||109068152||109068152-gold

Keywords: 2011

Offline analysis pipelines have been developed and evaluated for the detection of covert attention from electroen-cephalography recordings, and the detection of overt attention in terms of eye movement based on electrooculographic measurements. Some additional analysis were done in order to prepare the pipelines for use in a real-time system. This real-time system and a game application in which these pipelines are to be used were implemented. The game is set in a virtual environment where player is a wildlife photographer on an uninhabited island. Overt attention is used to adjust the angle of the first person camera, when the player is tracking animals. When making a photograph, the animal will flee when it notices it is looked at directly, so covert attention is required to get a good shot. Future work will entail user tests with this system to evaluate usability, user experience, and characteristics of the signals related to overt and covert attention when used in such an immersive environment. © 2011 IEEE.

Authors: repository Looking around with your brain in a virtual world

Journal: other-oa

Published: submittedVersion

DOI: false

Volume: http://hdl.handle.net/2066/92014 Pages: 104046451||111556336||108041704||104720030||103966353||105500741||104046451||104046451||104046451||103851499||104046451-green

Keywords: 2011

Background. In 2007, Schiff et al reported a patient in a minimally conscious state (MCS) who responded to deep brain stimulation (DBS), but clinicians cannot predict which patients might respond prior to the implantation of electrodes. Methods. A patient in a MCS for 5 years participated in an ABA design alternating between repetitive transcranial magnetic stimulation (rTMS) and peripheral nerve stimulation. rTMS (condition A) involved the delivery of 10 trains of 100 stimuli at 20 Hz using a stimulator with a 70-mm figure-of-eight coil to elicit a contraction of the abductor pollicis brevis. Condition B used median nerve electrical stimulation. Results. After peripheral stimulation, the patient did not exhibit clinical, behavioral, or electroencephalographic (EEG) changes. The frequency of specific and meaningful behaviors increased after rTMS, along with the absolute and relative power of the EEG δ, β, and α bands. Conclusion. These results suggest that rTMS may improve awareness and arousal in MCS. If these results are reproducible, rTMS may identify subgroups of MCS patients who might benefit from DBS. © The Author(s) 2011.

Authors: Behavioral and neurophysiological effects of repetitive transcranial magnetic stimulation on the minimally conscious state: A case study; 2011 Dept Neurorehabil

Journal: Behavioral and Neurophysiological Effects of Repetitive Transcranial Magnetic Stimulation on the Minimally Conscious State: A Case Study

Published: Piccione, F; Cavinato, M; Manganotti, P; Formaggio, E; Storti, SF; Battistin, L; Cagnin, A; Tonin, P; Dam, M;

DOI: false

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Volume: Piccione||Cavinato||Manganotti||Formaggio||Storti||Battistin||Cagnin||Tonin||Dam Pages: 110185926-closed

Keywords: 2011