IAS-LAB PUBLICATIONS
Belloni-Fortina A.; Piaserico S.; Tonin E.; Alaibac M.
Authors: Melanoma and immunosuppression; 2009 Unit Dermatol; Unit Dermatol; NCI
Journal: Melanoma and Immunosuppression
Published: Belloni-Fortina, A; Piaserico, S; Tonin, E; Alaibac, M;
DOI: false
WOS.SCI
Volume: Belloni-Fortina||Piaserico||Tonin||Alaibac Pages: 103061702||103061702||108397459||103061702-closed
Keywords: 2008
Background: Evoked potentials allow one to assess functional integrity of sensory pathways projecting to primary sensory cortices and event-related potentials assess higher order cortical functions associated with stimulus detection and decision-making. Evoked and event-related potentials have been used to predict emergence from coma. This study aimed to determine whether they can help prediction of consciousness recovery in post-traumatic vegetative state (VS). Methods: Thirty-four patients in post-traumatic VS were assessed clinically and neurophysiologically at 2-3 months after injury and followed up to 1 year. Patients were assessed with the Disability Rating Scale (DRS) and with electroencephalogram (EEG), brainstem auditory (BAEP) and somatosensory evoked potentials (SEP) and P300. Demographic, clinical and neurophysiological measures were analysed by descriptive and logistic regression techniques. Results: At 1 year from injury, 26 patients (76%) had recovered consciousness and eight patients (24%) had not. In univariate analyses, a detectable P300, a reactive EEG and lower DRS scores were found at entry assessment more frequently (p 0.05) in patients who later recovered consciousness than in those who did not. Logistic regression analysis revealed that P300 was the only factor contributing to prediction of conscious recovery with an area under the ROC curve of 0.94 (95% CI, 0.80-0.99). Conclusions: P300 is a strong predictor of conscious recovery in VS. © 2009 Informa Healthcare Ltd.
Authors: Post-acute P300 predicts recovery of consciousness from traumatic vegetative state; 2009 Ist Cura San Camillo; Dipartimento Farmacol & Anestesiol; Ist Cura San Camillo
Journal: Post-acute P300 predicts recovery of consciousness from traumatic vegetative state
Published: Cavinato, M; Freo, U; Ori, C; Zorzi, M; Tonin, P; Piccione, F; Merico, A;
DOI: false
WOS.SCI
Volume: Cavinato||Freo||Ori||Zorzi||Tonin||Piccione||Merico Pages: 123085330||103061708||103061708||123085330||123085330||123085330-closed
Keywords: 2009
Aims: To assess the role of type 2 diabetes as a risk factor for cognitive decline among elderly people. Methods: Analyses were carried out on data from the Italian Longitudinal Study on Aging, a study on 5,632 subjects aged 65-84 years, with baseline in 1992 and follow-ups in 1996 and 2000. Results:At baseline, diabetic women had significantly worse scores on all cognitive tests compared to nondiabetic women, but did not show worsening over time, whereas men with diabetes did not show worse scores on cognitive tests at baseline compared to nondiabetic males; however, diabetes in men was associated with a risk of cognitive decline over time, particularly in attention. Higher levels of HbA1c were associated with poorer performance on memory tests at follow-up in both sexes. Conclusion: The impact of diabetes on cognitive status might differ in older men and women, probably because of a survival effect, with a higher mortality at a younger age among diabetic men. The metabolic and cardiovascular abnormalities associated with diabetes might be responsible for the cognitive decline, at different rates and ages, in men and women. The routine assessment of diabetes complications in the elderly should include cognitive evaluation in both sexes. Copyright © 2008 S. Karger AG.
Authors: Diabetes as a risk factor for cognitive decline in older patients; 2009 Inst Neurosci; Inst Neurosci
Journal: Diabetes as a Risk Factor for Cognitive Decline in Older Patients
Published: Maggi, S; Limongi, F; Noale, M; Romanato, G; Tonin, P; Rozzini, R; Scafato, E; Crepaldi, G;
DOI: false
WOS.SCI
Volume: Maggi||Limongi||Noale||Romanato||Tonin||Rozzini||Scafato||Crepaldi Pages: 104076662||105462489||105462489||105462489||103061168-closed
Keywords: 2009
AREA MIN. 06 – Scienze mediche||AREA MIN. 06 – Scienze mediche – 2009
Authors: 2009 Unit Dermatol; Melanoma Unit; Dept Pediat; Unit Dermatol
Journal: Use of a manual dermatoscope with a compact digital camera in skin cancer triage
Published: Zattra, E; Tonin, E; Belloni-Fortina, A; Pigozzi, B; Alaibac, M;
DOI: English
WOS.SCI
AREA MIN. 06 – Scienze mediche – 2009
Authors: 2009 Unit Dermatol; Melanoma Unit; Dept Pediat; Unit Dermatol
Journal: Use of a manual dermatoscope with a compact digital camera in skin cancer triage
Published: Zattra, E; Tonin, E; Belloni-Fortina, A; Pigozzi, B; Alaibac, M;
DOI: English
WOS.SCI
This paper discusses and evaluates the role of shared control approach in a BCI-based telepresence framework. Driving a mobile device by using human brain signals might improve the quality of life of people suffering from severely physical disabilities. By means of a bidirectional audio/video connection to a robot, the BCI user is able to interact actively with relatives and friends located in different rooms. However, the control of robots through an uncertain channel as a BCI may be complicated and exhaustive. Shared control can facilitate the operation of brain-controlled telepresence robots, as demonstrated by the experimental results reported here. In fact, it allows all subjects to complete a rather complex task, driving the robot in a natural environment along a path with several targets and obstacles, in shorter times and with less number of mental commands. ©2010 IEEE.
Authors: repository The role of shared-control in BCI-based telepresence; 2010 Sch Engn; Sch Engn
Journal: cc-by-nc-nd
Published: Tonin, L; Leeb, R; Tavella, M; Perdikis, S; Millán, JD;
DOI: false
WOS.ISTP
Volume: https://infoscience.epfl.ch/record/150342/files/smc2010_finalversion.pdf Pages: 109900823||109900823||109900823||109900823||109900823-green
Keywords: 2010
This study intended to describe general personality functioning in patients with a progressive course of multiple sclerosis. 55 consecutive rehabilitation inpatients with progressive course of multiple sclerosis were assessed with a multimethod test battery: the Expanded Disability Status Scale, the Beck Depression Inventory, the State-Trait Anxiety Inventory, the Rosenberg Self-esteem Scale, and the Rorschach Test administered and scored with Comprehensive System. The control group comprised 55 healthy participants with similar sociodemographic characteristics. Specific differences were found for both cognitive and affective aspects, as the patients with progressive course of multiple sclerosis had less positive self-image, less effective mediation processing, and an affective approach to reality. Present data illustrated the usefulness of examining patients with a progressive course of multiple sclerosis to identify abilities and difficulties in cognitive and affective patterns, and support better adaptation to relationships and the environment. © Psychological Reports 2010.
Authors: Personality functioning in patients with a progressive course of multiple sclerosis; 2010 Ist Ricovero & Cura Carattere Sci
Journal: PERSONALITY FUNCTIONING IN PATIENTS WITH A PROGRESSIVE COURSE OF MULTIPLE SCLEROSIS
Published: Lorio, R; Moressa, G; Meneghello, F; Salcuni, S; Stabile, MR; Zennaro, A; Ferro, L; Tonin, P;
DOI: English
WOS.SSCI
Volume: Lorio||Moressa||Meneghello||Salcuni||Stabile||Zennaro||Ferro||Tonin Pages: 105654090-Dipartimento di Neuroriabilitazione;
Keywords: 2010
Background. Six months after a stroke, the hemiplegic arm often remains compromised. More innovative approaches to motor rehabilitation are needed. Objective. The authors compared a motor learning-based approach in a virtual environment with more conventional upper extremity therapy in a pilot trial. Methods. This prospective, single-blinded, randomized controlled trial compared reinforced feedback in a virtual environment (RFVE; n = 27) with a control intervention (n = 20) of progressive therapy for the affected upper extremity. Both treatments were provided for 4 weeks, 5 days per week, with 1-hour treatment sessions daily. The primary outcomes were the Fugl-Meyer Upper Extremity (F-M UE) and Functional Independence Measure (FIM) scores. Kinematic outcomes included mean duration (MD), mean linear velocity (MLV), and number of submovements to measure the motor performance. Analyses of the primary outcomes were performed per protocol and by intention to treat. Results. F-M UE scores improved significantly in the RFVE group compared with the conventional therapy group (“intention to treat” = 5.10 points, P =.004; ANCOVA = 4.26 points, P <.01). Several of the kinematic parameters improved in the RFVE group (MD, P <.01; MLV, P <.01). FIM improvements did not differ. Conclusions. Both rehabilitation therapies improved arm motor performance and functional activity, but the RFVE therapy induced more robust results in patients exposed to late rehabilitation treatment. © 2010 The Author(s).
Authors: publisher Motor learning principles for rehabilitation: A pilot randomized controlled study in poststroke patients; 2010 IRCCS; IRCCS; Dept Stat
Journal: Motor Learning Principles for Rehabilitation: A Pilot Randomized Controlled Study in Poststroke Patients
Published: Piron, L; Turolla, A; Agostini, M; Zucconi, CS; Ventura, L; Tonin, P; Dam, M;
DOI: false
WOS.SCI
Volume: https://journals.sagepub.com/doi/pdf/10.1177/1545968310362672 Pages: 103061186||109486218-bronze
Keywords: 2010
Coenzyme Q10 (CoQ10) deficiency has been associated with an increasing number of clinical phenotypes. Whereas primary CoQ10 defects are related to mutations in ubiquinone biosynthetic genes, which are now being unraveled, and respond well to CoQ10 supplementation, the etiologies, and clinical phenotypes related to secondary deficiencies are largely unknown. The purpose of this multicenter study was to evaluate the frequency of muscle CoQ10 deficiency in a cohort of 76 patients presenting with clinically heterogeneous mitochondrial phenotypes which included myopathy among their clinical features. A reliable diagnostic tool based on HPLC quantification was employed to measure muscle CoQ10 levels. A significant proportion of these patients (28 over 76) displayed CoQ10 deficiency that was clearly secondary in nine patients, who harbored a pathogenic mutation of mitochondrial DNA. This study provides a rationale for future therapeutic trials on the effect of CoQ10 supplementation in patients with mitochondrial diseases presenting with myopathy among clinical features. © 2009 Elsevier B.V. All rights reserved.
Authors: Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy; 2010 Nice Hosp; Dept Pediat; Serv Biochim; Ctr Invest; Neurol Clin; Dept Neurosci; AP HP
Journal: Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy
Published: Sacconi, S; Trevisson, E; Salviati, L; Aymé, S; Rigal, O; Redondo, AG; Mancuso, M; Siciliano, G; Tonin, P; Angelini, C; Auré, K; Lombès, A; Desnuelle, C;
DOI: false
WOS.SCI
Volume: Sacconi||Trevisson||Salviati||Aymé||Rigal||Garcia Redondo||Mancuso||Siciliano||Tonin||Angelini||Auré||Lombès||Desnuelle Pages: 120494007||100279593||100279593||103624749||108324026||102307702||108260608||123010475||123010475||120494007-closed
Keywords: 2010
In this paper we present the first results of users with disabilities in mentally controlling a telepresence robot, a rather complex task as the robot is continuously moving and the user must control it for a long period of time (over 6 minutes) to go along the whole path. These two users drove the telepresence robot from their clinic more than 100 km away. Remarkably, although the patients had never visited the location where the telepresence robot was operating, they achieve similar performances to a group of four healthy users who were familiar with the environment. In particular, the experimental results reported in this paper demonstrate the benefits of shared control for brain-controlled telepresence robots. It allows all subjects (including novel BMI subjects as our users with disabilities) to complete a complex task in similar time and with similar number of commands to those required by manual control. © 2011 IEEE.
Authors: Brain-controlled telepresence robot by motor-disabled people; 2011 Sch Engn; Sch Engn
Journal: cc-by-nc-nd
Published: Tonin, L; Carlson, T; Leeb, R; Millán, JD;
DOI: false
WOS.ISTP
Volume: Tonin||Carlson||Leeb||Del R. Millan Pages: 109068152||109068152||109068152||109068152-gold
Keywords: 2011