IAS-LAB PUBLICATIONS
Background: This pilot study compared the effects of lexical-semantic stimulation through telecommunication technology (LSS-tele) with in-person LSS (LSS-direct) and unstructured cognitive treatment (UCS) in patients with early Alzheimer’s disease.Methods: Twenty-seven patients with Alzheimer’s disease in the very early stage (Mini-Mental State Examination [MMSE] >26/30) were divided into three groups: seven patients received LSS-tele treatment, ten received standard LSS-direct intervention, and ten participants underwent UCS as control condition. Intervention treatments consisted of two weekly sessions of LSS (through teleconference or face to face depending on group assignment) or UCS exercises administered to small groups throughout a 3-month period. The main outcome measures were changes of global cognitive performance, language abilities, and memory function. Secondary outcome measures were changes in attention, working memory, executive functions, and visual-spatial abilities tests.Results: The mean MMSE score improved significantly in LSS-tele and LSS-direct treatments; LSS-tele improved language abilities, both phonemic and semantic, and stabilized delayed verbal episodic memory with respect to an improved performance after the LSS-direct intervention and to a memory decline observed in the control group. Improvement was not achieved in any neuropsychological test score after UCS.Conclusion: Clinical application of telecommunication technology to cognitive rehabilitation of elderly patients with neurodegenerative cognitive impairment is feasible and may improve global cognitive performance. Technical aspects to ameliorate efficacy of delivery may further improve its impact on domain-specific cognitive abilities.
Authors: publisher Feasibility and efficacy of cognitive telerehabilitation in early Alzheimer’s disease: A pilot study; 2014 Lab Kinemat & Robot; Lab Kinemat & Robot; Sci NPSRR
Journal: cc-by-nc
Published: Jelcic, N; Agostini, M; Meneghello, F; Busssé, C; Parise, S; Galano, A; Tonin, P; Dam, M; Cagnin, A;
DOI: true
WOS.SCI
Volume: https://www.dovepress.com/getfile.php?fileID=21744 Pages: 114681371||114681371||114681371||113433518||113433518||113433518||114681371||114681371||113433518-gold
Keywords: 2014
Neuromuscular diseases (NMDs) encompass a broad spectrum of conditions. Because infections may be relevant to the final prognosis of most NMDs, vaccination appears to be the simplest and most effective solution for protecting NMD patients from vaccine-preventable infections. However, very few studies have evaluated the immunogenicity, safety, tolerability, and efficacy of different vaccines in NMD patients; therefore, detailed vaccination recommendations for NMD patients are not available. Here, we present vaccination recommendations from a group of Italian Scientific Societies for optimal disease prevention in NMD patients that maintain high safety levels. We found that NMD patients can be classified into two groups according to immune function: patients with normal immunity and patients who are immunocompromised, including those who intermittently or continuously take immunosuppressive therapy. Patients with normal immunity and do not take immunosuppressive therapy can be vaccinated as healthy subjects. In contrast, immunocompromised patients, including those who take immunosuppressive therapy, should receive all inactivated vaccines as well as influenza and pneumococcal vaccines; these patients should not be administered live attenuated vaccines. In all cases, the efficacy and long-term persistence of immunity from vaccination in NMD patients can be lower than in normal subjects. Household contacts of immunocompromised NMD patients should also be vaccinated appropriately.
Authors: Vaccination recommendations for patients with neuromuscular disease; 2014 Osped Maggiore Policlin; Ctr Traslaz Miol & Patol Neurodegenerat; Neurol Natl Inst C Mondino; Sect Neuromuscular Dis & Neuropathies; Azienda Osped; Immunol & Neuromuscolar Dis Unit; Dept Neurosci; NPSRR; Dept Clin & Expt Med; Dept Neurol Sci & Movement; Multiple Sclerosis Ctr; Pediat Neurol & Neuromuscolar Dis Unit; Fdn IRCCS Ca Granda; Mol Med Unit; IRCCS AOU San Martino IST; Resp Pathophysiol Div; Osped Maggiore Policlin
Journal: Vaccination recommendations for patients with neuromuscular disease
Published: Esposito, S; Bruno, C; Berardinelli, A; Filosto, M; Mongini, T; Morandi, L; Musumeci, O; Pegoraro, E; Siciliano, G; Tonin, P; Marrosu, G; Minetti, C; Servida, M; Fiorillo, C; Conforti, G; Scapolan, S; Ansaldi, F; Vianello, A; Castaldi, S; Principi, N; Toscano, A; Moggio, M;
DOI: false
WOS.SCI
Volume: Esposito||Bruno||Berardinelli||Filosto||Mongini||Morandi||Musumeci||Pegoraro||Siciliano||Tonin||Marrosu||Minetti||Servida||Fiorillo||Conforti||Scapolan||Ansaldi||Vianello||Castaldi||Principi||Toscano||Moggio Pages: 104534016||113702973||114133667||127233992||114695923||113142508||113433518||113774660||112649785||114696203||114436169||114695773||108791176||127234247||127234247||117641962||104386205||105110405||104534016||113142508||114695773-closed
Keywords: 2014
Context: Bone fragility and low bone mass have been reported in small case series of patients with Pompe disease with severely reduced muscle strength or immobilization. Objective: Our objective was to determine the prevalence of morphometric vertebral fractures and to evaluate bone mass in adults with late-onset Pompe disease. Design: We conducted a multicenter cross-sectional observational study from August 2012 to December 2013. Study Setting: All subjects were outpatients referred to University Referral Centers. Patients: Patients included 22 late-onset Pompe disease patients with progressive proximal myopathy and minimal respiratory involvement without other diseases affecting bone mass. Main Outcome Measure: The prevalence of morphometric vertebral fractures was systematically assessed by semiquantitative analysis of lateral spine x-rays (T4-L5). Results: A high prevalence of morphometric vertebral fractures was found. At least 1 vertebral fracture was present in 17 of 22 patients (77%). All vertebral fractures were asymptomatic. Bone mineral density was normal in 36.5% of the patients, whereas 36.5% were osteopenic and 27% were osteoporotic in at least 1 site. Fracture prevalence was independent of muscular and respiratory functional parameters and of genotype. Conclusions: Our data show for the firsttime that asymptomatic and atraumatic vertebral fractures occur frequently in late-onset Pompe disease patients without a significant impairment of bone mass. Screening for asymptomatic vertebral fractures should be routinely performed in Pompe disease irrespective of the disease severity. Fracture risk should be confirmed in longitudinal studies.
Authors: Prevalence of asymptomatic vertebral fractures in late-onset pompe disease; 2015 Internal Med; Dept Neurol Sci; Internal Med; IRCCS Fdn Ca Granda Osped Maggiore Policlin; Dept Neurosci; Neurol Clin; Dept Publ Hlth & Neurosci
Journal: Prevalence of Asymptomatic Vertebral Fractures in Late-Onset Pompe Disease
Published: Bertoldo, F; Zappini, F; Brigo, M; Moggio, M; Lucchini, V; Angelini, C; Semplicini, C; Filosto, M; Ravaglia, S; Cotelli, S; Todeschini, A; Scarpelli, M; Pancheri, S; Tonin, P;
DOI: English
WOS.SCI
Volume: Bertoldo||Zappini||Brigo||Moggio||Lucchini||Angelini||Semplicini||Filosto||Ravaglia||Cotelli||Todeschini||Scarpelli||Pancheri||Tonin Pages: 126432838||126432838||115155190||115155190||113777717||113777717||113699233||111088154||113699233||113699233||126432838-Internal Medicine;Department of Medicine;||Department of Medicine;||Internal Medicine;Department of Medicine;||Neuromuscular Unit;IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico;||Neuromuscular Unit;IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico;||Dept. of Neurosci.;Sci. Sci. Neurologiche;Psichiatriche;Sensoriali;Ricostruttive;Riabilitative;||Dept. of Neurosci.;Sci. Sci. Neurologiche;Psichiatriche;Sensoriali;Ricostruttive;Riabilitative;||Clinical Neurology;Section for Neuromuscular Diseases and Neuropathies;||Department of Public Health and Neurosciences;||Clinical Neurology;Section for Neuromuscular Diseases and Neuropathies;||Clinical Neurology;Section for Neuromuscular Diseases and Neuropathies;||Department of Medicine;||Internal Medicine;Department of Medicine;||Department of Medicine;
Keywords: 2015
Background: Pompe’s disease is a progressive myopathy caused by mutations in the lysosomal enzyme acid alphaglucosidase gene (GAA). A wide clinical variability occurs also in patients sharing the same GAA mutations, even within the same family.Methods. For a large series of GSDII patients we collected some clinical data as age of onset of the disease, presence or absence of muscular pain, Walton score, 6-Minute Walking Test, Vital Capacity, and Creatine Kinase. DNA was extracted and tested for GAA mutations and some genetic polymorphisms able to influence muscle properties (ACE, ACTN3, AGT and PPAR genes). We compared the polymorphisms analyzed in groups of patients with Pompe disease clustered for their homogeneous genotype.Results: We have been able to identify four subgroups of patients completely homogeneous for their genotype, and two groups homogeneous as far as the second mutation is defined “very severe” or “potentially less severe”. When disease free life was studied we observed a high significant difference between groups. The DD genotype in the ACE gene and the XX genotype in the ACTN3 gene were significantly associated to an earlier age of onset of the disease. The ACE DD genotype was also associated to the presence of muscle pain.Conclusions: We demonstrate that ACE and ACTN3 polymorphisms are genetic factors able to modulate the clinical phenotype of patients affected with Pompe disease.
Authors: publisher Genotype-phenotype correlation in Pompe disease, a step forward; 2014 Dept Mol Med; Dept Mol Med; Reg Ctr Rare Dis; Dept Neurosci; Immunol & Muscular Pathol Unit; Dept Neurol; CeSI; Sect Neuromuscular Dis & Neuropathies; Dept Med Surg & Neurol Sci; Dept Cardiovasc Sci & Neurol; Rare Metab Dis Unit; Neurol Sect; Neurol Inst; Dept Pulm Rehabil; Dept Brain & Behav Sci; Dept Neurosci Psychiat & Anaesthesiol
Journal: cc-by
Published: De Filippi, P; Saeidi, K; Ravaglia, S; Dardis, A; Angelini, C; Mongini, T; Morandi, L; Moggio, M; Di Muzio, A; Filosto, M; Bembi, B; Giannini, F; Marrosu, G; Rigoldi, M; Tonin, P; Servidei, S; Siciliano, G; Carlucci, A; Scotti, C; Comelli, M; Toscano, A; Danesino, C;
DOI: true
WOS.SCI
Volume: https://ojrd.biomedcentral.com/counter/pdf/10.1186/s13023-014-0102-z Pages: 113855795||113855795||106171087||113699239||103893887||113267986||103274444||113699233||106171087||113511455||104639508||106402087||104638537||104623433||124800924||113855795||113396365||103618674||113855795-gold
Keywords: 2014
Action observation activates the same motor areas as those involved in the performance of the observed actions and promotes functional recovery following stroke. Movement observation is now considered a promising tool for motor rehabilitation, by allowing patients to train their motor functions when voluntary movement is partially impaired. We asked chronic-stroke patients, affected by either left (LHD) or right hemisphere (RHD) lesions, to observe either a left or right hand, while grasping a small target (eliciting a precision grip) or a large target (eliciting a whole hand grasp directed towards a target object). To better understand the effects of action observation on damaged motor circuits, we used transcranial magnetic stimulation (TMS) to induce motor evoked potentials (MEP) from two muscles of the unaffected hand in 10 completely hemiplegic participants. Results revealed that LHD patients showed MEP facilitation on the right (contralesional) M1 during action observation of hand-object interactions. In contrast, results showed no facilitation of the left (contralesional) M1 in RHD patients. Our results confirm that action observation might have a positive influence on the recovery of motor functions after stroke. Activating the motor system by means of action observation might provide a mechanism for improving function, at least in LHD patients. © 2014 Mattia Marangon et al.
Authors: publisher Lateralization of motor cortex excitability in stroke patients during action observation: A TMS study; 2014 Dept Gen Psychol; Dept Gen Psychol; Fdn Osped San Camillo; Dept Rehabil Med
Journal: cc-by
Published: Marangon, M; Priftis, K; Fedeli, M; Masiero, S; Tonin, P; Piccione, F;
DOI: false
WOS.SCI
Volume: https://downloads.hindawi.com/journals/bmri/2014/251041.pdf Pages: 103061402||109032687-hybrid
Keywords: 2014
The m.3243A>G “MELAS” (mitochondrial encephalopathy with lactic acidosis and stroke-like episodes) mutation is one of the most common point mutations of the mitochondrial DNA, but its phenotypic variability is incompletely understood. The aim of this study was to revise the phenotypic spectrum associated with the mitochondrial m.3243A>G mutation in 126 Italian carriers of the mutation, by a retrospective, database-based study (“Nation-wide Italian Collaborative Network of Mitochondrial Diseases”). Our results confirmed the high clinical heterogeneity of the m.3243A>G mutation. Hearing loss and diabetes were the most frequent clinical features, followed by stroke-like episodes. “MIDD” (maternally-inherited diabetes and deafness) and “PEO” (progressive external ophthalmoplegia) are nosographic terms without any real prognostic value, because these patients may be even more prone to the development of multisystem complications such as stroke-like episodes and heart involvement. The “MELAS” acronym is convincing and useful to denote patients with histological, biochemical and/or molecular evidence of mitochondrial disease who experience stroke-like episodes. Of note, we observed for the first time that male gender could represent a risk factor for the development of stroke-like episodes in Italian m.3243A>G carriers. Gender effect is not a new concept in mitochondrial medicine, but it has never been observed in MELAS. A better elucidation of the complex network linking mitochondrial dysfunction, apoptosis, estrogen effects and stroke-like episodes may hold therapeutic promises. © 2013 Springer-Verlag Berlin Heidelberg.
Authors: The m.3243A>G mitochondrial DNA mutation and related phenotypes. A matter of gender?; 2014 Neurol Clin; Neurol Clin; Mol Med Lab; IRCCS Fdn Ca Granda Osped Maggiore Policlin; A Meyer Childrens Hosp; G Gaslini Inst; Fdn IRCCS Ca Granda Osped Maggiore Policlin; Dept Neurosci; Inst Neurol; Fdn Carlo Besta Inst Neurol; Unit Mol Neurogenet
Journal: The m.3243A>G mitochondrial DNA mutation and related phenotypes. A matter of gender?
Published: Mancuso, M; Orsucci, D; Angelini, C; Bertini, E; Carelli, V; Comi, GP; Donati, A; Minetti, C; Moggio, M; Mongini, T; Servidei, S; Tonin, P; Toscano, A; Uziel, G; Bruno, C; Ienco, EC; Filosto, M; Lamperti, C; Catteruccia, M; Moroni, I; Musumeci, O; Pegoraro, E; Ronchi, D; Santorelli, FM; Sauchelli, D; Scarpelli, M; Sciacco, M; Valentino, ML; Vercelli, L; Zeviani, M; Siciliano, G;
DOI: false
WOS.SCI
Volume: Mancuso||Orsucci||Angelini||Bertini||Carelli||Comi||Donati||Minetti||Moggio||Mongini||Servidei||Tonin||Toscano||Uziel||Bruno||Ienco||Filosto||Lamperti||Catteruccia||Moroni||Musumeci||Pegoraro||Ronchi||Santorelli||Sauchelli||Scarpelli||Sciacco||Valentino||Vercelli||Zeviani||Siciliano Pages: 104458839||104458839||110935153||104534016||113263551||113240986||113699239||110185689||104638385||113142508||106952425||113263551||104458839||113699233||103894101||110935153||106952425||113142508||104534016||110185689||104638385||113240986||113699239||103894101||104458839-closed
Keywords: 2014
A major clinical goal of brain-computer interfaces (BCIs) is to allow severely paralyzed patients to communicate their needs and thoughts during their everyday lives. Among others, P300-based BCIs, which resort to EEG measurements, have been successfully operated by people with severe neuromuscular disabilities. Besides reducing the number of stimuli repetitions needed to detect the P300, a current challenge in P300-based BCI research is the simplification of system’s setup and maintenance by lowering the number N of recording channels. By using offline data collected in 30 subjects (21 amyotrophic lateral sclerosis patients and 9 controls) through a clinical BCI with N=5 channels, in the present paper we show that a preprocessing approach based on a Bayesian single-trial ERP estimation technique allows reducing N to 1 without affecting the system’s accuracy. The potentially great benefit for the practical usability of BCI devices (including patient acceptance) that would be given by the reduction of the number N of channels encourages further development of the present study, for example, in an online setting. © 2014 Anahita Goljahani et al.
Authors: publisher Preprocessing by a Bayesian single-trial event-related potential estimation technique allows feasibility of an assistive single-channel P300-based brain-computer interface; 2014 Dept Informat Engn; Dept Informat Engn
Journal: cc-by
Published: Goljahani, A; D'Avanzo, C; Silvoni, S; Tonin, P; Piccione, F; Sparacino, G;
DOI: false
WOS.SCI
Volume: https://downloads.hindawi.com/journals/cmmm/2014/731046.pdf Pages: 112347030||112347030||112347030-hybrid
Keywords: 2014
08/03/2026 05:58:54
Authors: AREA MIN. 06 - Scienze mediche; AREA MIN. 09 - Ingegneria industriale e dell'informazione; ITA; ERROR; 1
Published: 8th World Congress for NeuroRehabilitation - Book of abstracts
Pages: ERROR_NO_MATCH
5
Authors: publisher The host galaxies of X-ray selected active galactic nuclei to z = 2.5: Structure, star formation, and their relationships from CANDELS and Herschel/PACS; 2015
Journal: The host galaxies of X- ray selected active galactic nuclei to z=2.5: Structure, star formation, and their relationships from CANDELS and Herschel/PACS
Published: Rosario, DJ; McIntosh, DH; van der Wel, A; Kartaltepe, J; Lang, P; Santini, P; Wuyts, S; Lutz, D; Rafelski, M; Villforth, C; Alexander, DM; Bauer, FE; Bell, EF; Berta, S; Brandt, WN; Conselice, CJ; Dekel, A; Faber, SM; Ferguson, HC; Genzel, R; Grogin, NA; Kocevski, DD; Koekemoer, AM; Koo, DC; Lotz, JM; Magnelli, B; Maiolino, R; Mozena, M; Mullaney, JR; Papovich, CJ; Popesso, P; Tacconi, LJ; Trump, JR; Avadhuta, S; Bassett, R; Bell, A; Bernyk, M; Bournaud, F; Cassata, P; Cheung, E; Croton, D; Donley, J; DeGroot, L; Guedes, J; Hathi, N; Herrington, J; Hilton, M; Lai, K; Lani, C; Martig, M; McGrath, E; Mutch, S; Mortlock, A; McPartland, C; O'Leary, E; Peth, M; Pillepich, A; Poole, G; Snyder, D; Straughn, A; Telford, O; Tonini, C; Wandro, P;
DOI: true
WOS.SCI
Volume: https://www.aanda.org/articles/aa/pdf/2015/01/aa23782-14.pdf
Keywords: 2015
This paper presents an important step forward towards increasing the independence of people with severe motor disabilities, by using brain-computer interfaces to harness the power of the Internet of Things. We analyze the stability of brain signals as end-users with motor disabilities progress from performing simple standard on-screen training tasks to interacting with real devices in the real world. Furthermore, we demonstrate how the concept of shared control – which interprets the user’s commands in context – empowers users to perform rather complex tasks without a high workload. We present the results of nine end-users with motor disabilities who were able to complete navigation tasks with a telepresence robot successfully in a remote environment (in some cases in a different country) that they had never previously visited. Moreover, these end-users achieved similar levels of performance to a control group of 10 healthy users who were already familiar with the environment.
Authors: repository Towards independence: A BCI telepresence robot for people with severe motor disabilities; 2015 Ctr Neuroprosthet; Dept Informat Engn; Aspire Ctr Rehabil Engn & Assist Technol; Ctr Neuroprosthet
Journal: Towards Independence: A BCI Telepresence Robot for People With SevereMotor Disabilities
Published: Leeb, R; Tonin, L; Rohm, M; Desideri, L; Carlson, T; Millan, JD;
DOI: false
WOS.SCI
Volume: Leeb||Tonin||Rohm||Desideri||Carlson||Millán Pages: 107144069||112347030||113876419-green
Keywords: 2015